李云　张炜华　岳宝森　杨帅　职媛　吕楠

[摘要] 目的 采用正交试验设计，运用多指标综合评价手段，优化健儿膏的收膏成型工艺，控制膏方质量。 方法 以膏方的得膏率、膏滋含水量、膏滋动力黏度为评价指标，以清膏相对密度（A）、蜂蜜量（B）、膏滋相对密度（C）为影响因素，采用L9（34）正交试验，考察不同影响因素对健儿膏收膏成型工艺的影响，并优化健儿膏的收膏成型工艺。 结果 清膏相对密度（A）、蜂蜜量（B）、膏滋相对密度（C）三种因素对健儿膏收膏成型工艺的影响顺序为：A﹥C﹥B，最优工艺条件为：A3B2C2。即：将健儿膏复方水煎液加热浓缩至相对密度为1.25的清膏，在浓缩收膏过程中加入与清膏质量比为1∶2的蜂蜜，最终浓缩至相对密度为1.42的膏滋，此时健儿膏的成型性最佳。在此条件下进行工艺放大验证试验，所得实际成型性平均值为94.26，RSD值为0.87%。此验证结果数据无论在单因素实验还是正交实验中均处于较高的水平。 结论 上述工艺合理可行，所选各项工艺指标稳定可靠，能够对健儿膏的收膏成型工艺进行准确有效的控制。

[关键词] 健儿膏；成型工艺；相对密度；正交试验

[中图分类号] R914 [文献标识码] A [文章编号] 1673-7210（2016）10（a）-0028-04

Optimizing preparation technology of Jianer Paste by multi-target orthogonal test

LI Yun ZHANG Weihua YUE Baosen YANG Shuai ZHI Yuan LU Nan

Department of Pharmacy， Xi 'an Hospital of Traditional Chinese Medicine， Shaanxi Province， Xi'an 710021， China

[Abstract] Objective To optimize the preparation technology and control the quality of Jianer Paste by orthogonal experimental design and using multi-index comprehensive evaluation. Methods The coefficient of paste， moisture content and kinetic viscosity of decocted extract were used as evaluation indexes， and the relative density of clear paste （A）， honey dosage （B） and the relative density of decocted extract （C） were selected as experimental factors. L9（34） orthogonal experiment was used to study the effect of different influence factors on the preparation technology of Jianer paste. Results The influence degree of the three factors on the preparation technology： the relative density of clear paste﹥the relative density of decocted extract﹥honey dosage， and the optimum preparation technology for Jianer Paste was： control the relative density of clear paste to 1.25， the proportion of clear paste and honey adjusted to 1∶2， and control the relative density of decocted extract to 1.42. Under this condition， Jianer Paste had the best formability. Validation test under the condition， the actual values of formability was 94.26， the relative standard deviation was 0.87%. The verification results in single factor experiments and orthogonal experiments were at high levels. Conclusion This technology is reasonable and practical， each process index is stable and reliable， can effectively control the preparation technology of Jianer Paste.

[Key words] Jianer Paste； Preparation technology； Relative density； Orthogonal experiment

随着大健康理念的不断深入，越来越多的人选择膏方进补以达到未病先防的目的。膏方又称煎膏剂，是在中药汤剂的基础上，根据患者的证候、体质以及具体症状选择适宜的辅料浓缩而成的稠厚半流体状浸出制剂，是一种具有滋补调理和防治疾病作用的中药剂型[1]。目前有关膏方成型工艺的文献报道较少，其制作工艺及质量控制多以经验为依据，缺乏量化工艺评价指标。……