雷爱春+丁满秀+邓冬兰

摘 要 目的：探讨聚焦超声治疗高危型人乳头瘤病毒感染宫颈炎的临床疗效。方法：选取高危型人乳头瘤病毒感染宫颈炎患者100例，根据治疗意愿将其分为两组各50例，对照组采用重组人干扰素a-2b凝胶治疗，研究组采用聚焦超声治疗，比较两组患者临床疗效的差异。结果：治疗后3个月，研究组治疗总有效率（96.0%）明显高于对照组（52.0%）（P<0.05）。研究组治疗后3、6个月HPV转阴率分别为50.0%、96.0%，明显高于对照组（20.00%、42.00%）（P<0.05）。两组不良反应发生率比较差异无统计学意义。结论：聚焦超声有助于显著改善高危型HPV感染宫颈炎患者干扰素药物治疗的疗效，有助于提高宫颈炎治愈率与HPV转阴率，且无明显不良反应。

关键词 聚焦超声 高危型人乳头瘤病毒 感染 宫颈炎

中图分类号：R711.32； R454.3 文献标识码：A 文章编号：1006-1533（2016）21-0044-03

Clinical curative effect of focused ultrasound in the treatment of 50 cases of cervicitis patients with high risk human papilloma virus infection*

LEI Aichun**， DING Manxiu， DENG Donglan（Department of Obstetrics and Gynecology， Maternal and Child Health Hospital of Wanzai County in Yichun City， Yichun 336000， China）

ABSTRACT Objective： To discuss the clinical curative effect of focused ultrasound in the treatment of cervicitis patients with high risk human papilloma virus infection. Methods： One hundred cervicitis patients with high risk human papilloma virus infection were divided into a research group and a control group with 50 cases each according to their wish to the treatment. The control group was treated with human recombinant interferon a-2b gel and the research group with focused ultrasound. The clinical efficacy was compared between the two groups. Results： The total effective rate was significantly higher in the research group than in the control group （96.0% vs 52.0%） three months after treatment （P<0.05） and HPV negative rates at 3 or 6 months after treatment were 50.0% and 96.0% in the research group and 20.00% and 42.00% in the control group and were significantly higher in the research group than in the control group （P<0.05）. There was no statistical significance in the incidence of adverse reactions （P>0.05）. Conclusion： Focused ultrasound is helpful to improve the curative efficacy in the treatment of the patients and is of benefit to improving the cure rate of cervicitis and HPV negative rates without obvious adverse reaction.

KEY WORDS focused ultrasound； high risk human papilloma virus ； infection； cervicitis

慢性宫颈炎是常见的妇科疾病，就诊率占妇科门诊50%以上，高危型人乳头瘤病毒（human papilloma virus，HPV）感染是宫颈炎发展至宫颈癌的重要危险因素之一[1]。因此，对于合并高危型HPV感染宫颈炎需进行早期积极干预，有助于降低宫颈癌发生与死亡风险。目前，临床用于治疗高危性HPV感染宫颈炎患者的手段有宫颈环形电切术（loop electrosurgical excision procedure，LEEP）、电灼、冷冻、激光、重组人干扰素（interferon，IFN）a-2b凝胶治疗与期待疗法等[2]。但关于高危型HPV感染宫颈炎的最为理想的治疗手段尚无明确的定论。本研究探讨聚焦超声治疗高危型人乳头瘤病毒感染宫颈炎的临床疗效，以探寻更有效，更安全的治疗方案，现报道如下。

1 资料与方法

1.1 临床资料

选取2015年1月至2016年3月期间宜春市万载县妇幼保健院宫颈疾病门诊就诊的高危型HPV感染宫颈炎患者100例。纳入标准：全部患者均符合高危型HPV感染宫颈炎的诊断标准[3]，即经杂交捕获化学发光法检测高危型（+）且持续6个月以上，宫颈、阴道检查确定为慢性宫颈炎（表现为糜烂型，伴分泌物增多或接触性出血），年龄25～50岁，有性生活，宫颈细胞学检测未见癌细胞与异常上皮细胞，3个月内未接受宫颈物理治疗，自愿参加本研究试验。……