冯红兵

【摘要】根据国内外的多项调查研究显示：冠心病合并糖尿病支架后再狭窄发病率在逐年增高，并继而伴随多种并发症如高血糖、高血脂、高尿酸血症、高糖化血红蛋白等，甚至有特异性动脉闭塞等症状，这些高危因素都直接或间接影响凝血异常、内皮功能，最终导致再狭窄的发生。本文首先介绍了冠心病合并糖尿病患者发生再狭窄的机制，其次详细分析了患者发生再狭窄的危险因素及防治策略，最后对冠心病合并糖尿病患者进行总结。

【关键词】冠心病；糖尿病；再狭窄；研究进展

【中图分类号】R587.1；R541.4 【文献标识码】A 【文章编号】ISSN.2095-6681.2016.14.0.04

and foreign many investigation and study：diabetes mellitus complicated with coronary heart disease after stent restenosis incidence increased year by year，and then with a variety of complications such as high blood glucose，dyslipidemia，hyperuricemia，glycosylated hemoglobin，and even specific arterial occlusion and other symptoms，these risk factors are directly or indirectly influence coagulation abnormalities，endothelial function，eventually leading to restenosis.In this paper，we introduce the mechanism of restenosis in patients with coronary heart disease complicated with diabetes mellitus，followed by a detailed analysis of the patients with restenosis risk factors and prevention strategies and finally on coronary heart disease with diabetes patients are summarized.

【Key words】Coronary heart disease；diabetes mellitus；Restenosis；research progress

21世纪小康世纪的来临，人们生活水平不断提高，生活方式也不断改变，导致糖尿病的发病率越来越高，而糖尿病是诱发冠心病的高危因素。对于这两种疾病特点相似，而且病理机制出现较多的交集。根据目前医疗水平进展，临床上冠心病患者主要采取冠脉介入治疗，术后恢复供血，但对于引起冠状动脉狭窄硬化的高危因素仍不可避免，而近年来发生再次狭窄几率也在大大增加[1]。因此，探讨研究支架植入手术再狭窄的病理生理反应成为目前探索热点。依据研究结果表明，冠心病合并糖尿病患者冠状动脉再闭塞概率大约是糖尿病患者2倍。研究导致冠心病合并糖尿病再狭窄发生机制，对从患者提供根本的治疗有一定策略。现将其综述如下。

1 冠心病合并介入治疗再狭窄发生机制

1.1 机体内皮功能发生障……