连蔚 罗一平 田小燕 梁美燕

【摘要】目的：研究观察宫腔内人工授精促排卵周期中使用促性腺激素释放激素激动剂（GnRha）诱导卵泡成熟的效果。方法：从2013年4月至2014年4月，选择我院入院实施宫腔内授精治疗的100例不孕女性进行研究，以数字法随机分为观察组以及对照组，每组各50例。对观察组在促排卵周期中使用GnRha诱导卵泡成熟，对照组使用人绒毛膜促性腺激素（hCG）。观察对比两组疗效。结果：两组经过不同方式诱导卵泡成熟，排卵率，未破裂卵泡黄素化综合征以及临床妊娠率无较大差异；然而观察组的卵巢过度刺激综合征发生率明显小于对照组。对比结果表明，观察组与对照组的评分在干预之后均得到明显调节；但是观察组的降低程度明显优于对照组。两组患者实施不同方式之后，观察组患者效果显著优于对照组。两组在干预之前生活质量的各指标水平比较无显著差异。在进行干预后两组指标水平均上升，并且观察组均大于对照组。差异均有统计学意义（均P<0.05）。结论：宫腔内人工授精促排卵周期中使用GnRha诱导卵泡成熟效果较好，降低了卵巢过度刺激综合征的发生率。有效提升患者的生活质量，安全性较高。

【关键词】宫腔内；人工授精；促排卵；促性腺激素释放激素激动剂；卵泡成熟

Curative effect of GnRha induced oocyte maturation in intrauterine insemination cyclesLIAN Wei， LUO Yiping， TIAN Xiaoyan， LIANG Meiyan. Department of Obstetrics and Gynecology， Shunde First Peoples Hospital， Foshan 528300， Guangdong， China

【Abstract】Objectives： To observe the curative effect of GnRha induced oocyte maturation in intrauterine insemination cycles. Methods： 100 couples receiving treatment of intrauterine insemination in our hospital from April 2013 to April 2014 were selected and randomly divided into observation group and control group， with 50 couples in each group. The observation group was treated with GnRha to induce follicular maturation in the cycle of ovulation； the control group used human chorionic gonadotropin （HCG）. Curative effects of the two groups were compared. Results： After different induction of follicular maturation， ovulation rate， syndrome and clinical pregnancy rate of unruptured luteinized follicles in the two groups had no significant difference； however， the incidence of OHSS in observation group was significantly less than that in control group. The observation group and the control group were significantly regulated after the intervention； but the decrease in observation group was significantly better than that in control group. After the implementation of different ways， the effect in the observation group was significantly better than that in control group. There was no significant difference in each index level between the two groups before the intervention. The index levels of the two groups were increased after the intervention， higher in the observation group， with statistically significant differences （all P<0.05）. Conclusion： GnRha induced oocyte maturation in intrauterine insemination cycles can reduce the incidence of ovarian hyperstimulation syndrome and improve the quality of life of patients， with higher safety.

【Key words】Intrauterine； Artificial insemination； Ovulation induction； GnRha； Follicle

【中图分类号】R711.6【文献标志码】A

现如今，在我国的育龄夫妇中，不孕不育的比例高达10%，并且仍然呈现出上升趋势。宫腔内人工授精指的是使用一种较为经济、安全并且便于广泛应用的辅助助孕技术[1-3]。对不孕患者实施促排卵治疗成为目前临床的热点。人绒毛膜促性腺激素（hCG）对于诱导卵泡成熟具有一定的效果，然而会致使多卵泡发育以及卵巢过度刺激综合征的发生，多胎妊娠的发生几率较高。……