蒋晓秋 赵辉 徐莉峰 倪婷婷 李茂宇 王佩蓉

【摘要】目的：探讨卡介菌多糖核酸联合膦甲酸钠治疗复发性生殖器疱疹的疗效。方法：选取我院收治的118例复发性生殖器疱疹患者，将其随机分为观察组以及对照组，每组59例，对照组予以膦甲酸钠静脉滴注，观察组在此基础上肌肉注射卡介菌多糖核酸制剂进行治疗，比较两组治疗效果。结果：治疗前两组患者的CD4+、CD8+、CD4+/CD8+指标以及SDS、SAS评分比较无明显差异，治疗后均较治疗前明显改善，且观察组改善更明显；观察组治疗后3、6个月的平均复发频率以及皮损愈合时间均明显低于治疗前，生活质量评分较治疗前明显改善，且治疗后3个月与6个月相关指标比较有统计学差异，P<0.05；观察组的治疗有效率为91.53%（54/59），对照组为71.19%（42/59），组间比较有显著性差异（χ2=6.197，P<0.05）。结论：卡介菌多糖核酸联合膦甲酸钠治疗复发性生殖器疱疹能够改善患者的免疫状态，提高治疗效果，降低复发率，且不良反应较小，值得推广应用。

【关键词】卡介菌多糖核酸；膦甲酸钠；复发性生殖器疱疹

Effect of BCG polysaccharide nucleic acid joint phosphine formic acid sodium in the treatment of recurrent genital herpesJIANG Xiaoqiu1， ZHAO Hui1， XU Lifeng1， NI Tingting2， LI Maoyu2， WANG Peirong3. 1.Department of Gynecology， Changxing Zhizhou Hospital， Huzhou 313100， Zhejiang， China； 2.Department of Gynecology， Huzhou Maternal and Children Health Care Center， Huzhou 313000， Zhejiang， China； 3.Department of Psychiatry， Xianlin Branch， Zhejiang Provincial Tongde Hospital， Hangzhou 311122， Zhejiang， China

【Abstract】Objectives： To study the effect of BCG polysaccharide nucleic acid joint phosphine formic acid sodium in the treatment of recurrent genital herpes. Methods： 118 patients with recurrent genital herpes in our hospital were randomly divided into observation group and control group， with 59 cases in each group. Control group received phosphine formic acid sodium for intravenous drip treatment and observation group received BCG polysaccharide nucleic acid joint phosphine formic acid sodium for intramuscular injection. Therapeutic effects of two groups were compared. Results： CD4+， CD8+， CD4+ / CD8+ indexes and SDS， SAS score of two groups before treatment had no obvious difference. After treatment the indexes of both groups obviously improved， more significant in observation group. 3， 6 months after treatment， the recurrence rate and skin lesion healing time of observation group were significantly lower than these before treatment. The score of life quality was obviously improved. 3， 6 month after treatment， related indicators in observation group were significantly lower than these before treatment， P< 0.05. The treatment effective rate was 91.53% （54/59） in observation group and 71.19% in control group， with statistically significant difference （χ2 = 6.197， P< 0.05）. Conclusion： BCG polysaccharide nucleic acid joint phosphine formic acid sodium in the treatment of patients with recurrent genital herpes can improve immune status， improve the treatment effect， reduce the recurrence rate， and has less adverse reactions， which is worthy of popularization and application.

【Key words】BCG polysaccharide nucleic acid； Phosphine formic acid sodium； Recurrent genital herpes

【中图分类号】R752.1【文献标志码】A

生殖器疱疹的主要发病原因是由于单纯疱疹病毒（HSV-2）感染所导致的，其发病率以及复发率均较高，对人类的健康产生了十分严重的危害。感染后患者一般会终生携带病原体[1]，病毒主要存在于女性的宫颈、阴道、外阴以及男性的阴茎和尿道中，在性交过程中由于生殖器的表面黏膜受到磨擦作用而导致病毒出现扩散，诱发表皮损伤而发病。大多数病毒会潜伏在骶周围神经节中，因神经细胞缺乏病毒繁殖所需要的特异性转录酶，所以病毒会长期在神经细胞中保持静止不变[2]，当机体受到外界因素的刺激作用后，神经细胞会重新激活此酶，引起病毒繁殖，导致疾病复发。……