何国霞 李红梅

【摘要】目的：分析并探讨妇科恶性肿瘤宫颈癌、卵巢癌的发生与感染梅毒螺旋体的关系。方法：选取2005年1月至2015年5月期间来我院接受治疗的妇科恶性肿瘤宫颈癌658例、卵巢癌246例，检测肿瘤患者梅毒螺旋体感染情况，分析妇科肿瘤宫颈癌和卵巢癌对梅毒螺旋体感染的发生影响。结果：658例宫颈癌患者中合并梅毒螺旋体感染患者68例（10.33%），246例卵巢癌患者合并梅毒螺旋体感染患者4例（1.63%）。宫颈癌合并梅毒螺旋体感染率明显高于卵巢癌（P<0.05）。病理类型分析结果显示，鳞癌患者594例，其中梅毒感染者68例，而腺癌56例、腺鳞癌8例患者中均无梅毒感染者；Ⅰ期肿瘤患者354例，梅毒感染58例；Ⅱ期304例，梅毒感染10例。年龄分析结果显示，30～39岁136例，梅毒感染32例（23.53%）；40～49岁170例，梅毒感染30例（17.65%）；年龄50～59岁258例，梅毒感染6例（2.33%）；年龄60岁以上94例，梅毒感染0例。教育水平结果显示，高中及高中以上264例，梅毒感染6例（2.27%）；高中以下394例，梅毒感染62例（15.74%）。结论：宫颈癌患者梅毒螺旋体感染率明显高于卵巢癌患者，且与年龄、教育水平和病理类型、病理分期相关，为临床防治提供理论支持。

【关键词】宫颈癌；卵巢癌；梅毒螺旋体

Relationship between gynecological malignancies cervical cancer， ovarian cancer and syphlilisHE Guoxia1， LI Hongmei2. 1. Department of Obstetrics and Gynecology，Zhuji No.4 Peoples Hospital， Shaoxing 311835， Zhejiang， China； 2. Department of Obstetrics and Gynecology， Shaoxing Maternal and Children Care Hospital， Shaoxing 312000， Zhejiang， China

【Abstract】Objectives： To analyze and discuss the relationships between gynecological cervical cancer， ovarian cancer and infection of treponema pallidum. Methods： 658 cases of cervical cancer and 246 cases of ovarian cancer treated in our hospital from January 2005 to May 2015 were selected. Syphilis infection of these patients was detected. The impact of treponema pallidum infection on cervical cancer and ovarian cancer were analyzed. Results： In the 658 cases of cervical cancer， there were 68 cases of syphilis spirochete infection， accounting for 10.33%. In the 246 cases of ovarian cancer， there were 4 cases of syphilis spirochete infection， accounting for 1.63%. Syphilis infection rate in cervical cancer patients was significantly higher than that in ovarian cancer patients， with statistically significant difference （P<0.05）. Pathology analysis showed that there were 594 cases of squamous cell carcinoma， among which there were 68 cases of syphilis. In the 56 cases of adenocarcinoma and 8 cases of adeno-squamous cell carcinoma， there was no syphilis infection case. There were 58 cases of syphilis among 354 cases of staging I cancer. There were 10 cases of syphilis among 304 cases of staging II cancer. Age analysis showed that there were 136 cases in 30-39 years old patients， among which there were 32 cases of syphilis. In 40-49 years old patients， there were 170 cases， with 30 cases of syphilis. In 50-59 years old patients， there were 258 cases， with 6cases of syphilis. In over 60 years old patients， there were 94 cases， with 0 cases of syphilis. The level of education analysis results showed that there were 264 cases with high school or higher education level， among which there were 6 cases of syphilis. In patient with lower than high school education level， there were 394 cases， with 62 cases of syphilis. Conclusion： The prevalence of syphilis in patients with cervical cancer is significantly higher than that in ovarian cancer patients and is correlated with age， educational level， histological type and pathological staging， which provides theoretical support for the prevention and treatment.

【Key words】Cervical cancer； Ovarian cancer； Treponema pallidum

【中图分类号】R737.3【文献标志码】A

子宫颈癌是最常见的妇科恶性肿瘤，而卵巢癌亦是女性生殖器常见的三大恶性肿瘤之一[1]，宫颈癌在发生发展过程中与人乳头瘤病毒感染及性接触均有一定相关性，而卵巢癌目前的研究则表明其与致癌及抑癌基因变异相关[2]。除人乳头瘤病毒外，梅毒螺旋体因其性传播的特点一直在宫颈癌及卵巢癌中备受关注[3]，在本次研究中，选取2005年1月至2015年5月期间来我院接受治疗的妇科恶性肿瘤宫颈癌658例，卵巢癌246例，分析并探讨妇科恶性肿瘤宫颈癌、卵巢癌的发生与感染梅毒螺旋体的关系。

1资料与方法

1.1一般资料

选取2005年1月至2015年5月期间来我院接受治疗的妇科恶性肿瘤宫颈癌658例，卵巢癌246例。年龄30～71岁，平均年龄（48.12±5.23）岁。纳入标准[4]：（1）所有患者经病理学均确诊为宫颈癌或卵巢癌；（2）均接受手术治疗；（3）自愿参加本次研究；（4）均进行梅毒螺旋体排查。排除标准：（1）合并其他系统严重疾病；……