汪坚强 朱志侠

血液灌流在急诊急性中毒患者中的应用

汪坚强 朱志侠

目的 评价血液灌流治疗急性中毒的临床效果。方法 选取我院急诊科急性中毒患者182例，实验组89例，对照组93例。对照组给予常规治疗，实验组在此基础上给予血液灌流治疗，观察两组患者在临床疗效及生化学指标的变化。结果 经过血液灌流治疗后，实验组的意识恢复时间、住院天数、治愈情况均优于对照组，在死亡人数方面低于对照组，差异存在统计学意义（P＜0.05）；实验组患者治疗后各生化指标均有不同程度的降低，且差异存在统计学意义（P＜0.05）。结论 血液灌流可以提高患者的临床治疗效果，降低毒物对各脏器的损害。

血液灌流；急性中毒；治疗效果

【Abstract】

Objective To evaluate the effects of hemoperfusion in the treatment of acute poisoning. Methods Chose 182 patients with acute poisoning who were admitted to emergency department of our hospital and were divided into treatment group（89 patients） and control group（93 patients）. Patients with control group were treated with conventional treatments and treatment group were treated with hemoperfusion on the basis of conventional treatments. Then observe the difference of clinical effects and biochemical index. Results The time of consciousness recovery，hospital stays and treatment conditions of patients in treatment group were superior to the control group，and the death toll of patients in treatment group was inferior to the control group（P＜ 0.05）. The level of biochemical index was inferior to the control group（P＜0.05）. Conclusion Hemoperfusion can significantly improve clinical therapeutic effect of patients with acute poisoning，reduce the organs injury.

【Key words】Hemoperfusion，Acute poisoning，Therapeutic effect

急性中毒起病急骤，病情发展迅速，临床病死率及致残率较高，严重威胁患者生命及生存质量［1］。早期及时采取有效合理的措施，能够有效降低患者机体器官的损害，减低死亡率及致残率，对机体恢复有利。血液灌流（HP）主要通过吸附作用，使患者血液通过有解毒作用的灌流器中，清除其中有毒物质，达到净化的目的［2］。近年来，HP在临床上效果显著，成为常用解毒技术之一。因此本研究选取在我院急诊科就诊的急性中毒患者182例，实验组在常规治疗的基础上给予HP技术，观察HP对急性中毒患者的疗效，以期为临床应用提供理论基础。

1　对象与方法

1.1一般资料

选取2013～2015年在我院急诊科就诊的急性中毒患者182例，男85例，女97例，年龄15～74岁，平均（36.3±8.7）岁。所有患者经确诊为急性中毒。……