韦　颖

广西壮族自治区河池市人民医院心血管内科，广西河池547000

复方丹参滴丸联合坎地沙坦酯片治疗老年慢性心力衰竭的疗效及安全性

韦颖

广西壮族自治区河池市人民医院心血管内科，广西河池547000

目的探讨复方丹参滴丸联合坎地沙坦酯片治疗老年慢性心力衰竭（chronic heart failure，CHF）的疗效及安全性。方法选取80例CHF患者，随机分为观察组和对照组，每组40例。对照组仅给予坎地沙坦酯片，观察组给予复方丹参滴丸联合坎地沙坦酯片。比较两组左心室射血分数（left ventricular ejection fraction，LVEF）、左室舒张末期内径（left ventricular end diastolic diameter，LVEDD）、6 min步行距离、脑钠肽（brain natriuretic peptide，BNP）、肿瘤坏死因子-α（tumor necrosis factor-α，TNF-α）、超敏C反应蛋白（high sensitivity C-reactive protein，hs-CRP）、临床疗效及不良反应发生率。结果治疗后，与对照组比较，观察组LVEDD显著降低，同时LVEF及6 min步行距离显著增高（P＜0.05）；观察组血清BNP、TNF-α及hs-CRP水平较对照组显著降低（P＜0.05）。观察组临床疗效显著优于对照组（P＜0.05）。两组不良反应发生率比较差异无统计学意义（P＞0.05）。结论复方丹参滴丸联合坎地沙坦酯片治疗CHF可显著改善心功能，减轻炎症反应。

慢性心力衰竭曰复方丹参滴丸曰坎地沙坦酯片曰老年

[Abstract]Objective To discuss the curative effects and safety of compound danshen dripping pills combined with candesartan cilexetil tablets in the treatment of elderly chronic heart failure（CHF）.Methods 80 patients with CHF were selected，and were randomly assigned to the observation group and the control group，with 40 patients in each group. The control group was only given candesartan cilexetil tablets，and the observation group was given compound danshen dripping pills combined with candesartan cilexetil tablets.Left ventricular ejection fraction（LVEF），left ventricular end diastolic diameter（LVEDD），6-min walking distance，brain natriuretic peptide（BNP），tumor necrosis factor-α（TNF-α），high sensitivity C-reactive protein（hs-CRP），clinical curative effects and incidence rate of adverse reactions were compared between the two groups.Results After the treatment，LVEDD in the observation group was lower than that in the control group，LVEF and 6-min walking distance in the observation group were significantly higher than those in the control group（P＜0.05）；serum BNP，TNF-α and IL-6 levels were significantly lower than those in the control group（P＜0.05）.The clinical curative effects in the observation group were significantly better than those in the control group（P＜0.05）.There was no statistically significant difference of the incidence of adverse reactions between the two groups（P＞0.05）.Conclusion Compound danshen dripping pills combined with candesartan cilexetil tablets in the treatment of CHF are able to significantly improve cardiac function and reduce inflammatory reactions.

[Key words]Chronic heart failure；Compound danshen dripping pills；Candesartan cilexetil tablets；Elderly

慢性心力衰竭（chronic heart failure，CHF）是指由于多种因素引起的心肌损伤，造成心肌结构和功能改变，最终导致心室泵血或充盈功能低下［1］。据统计，CHF的患病率约为1.5%～2.0%，且发病率随年龄增长有明显上升趋势，65岁以上人群CHF发病率高达6%～10%，5年生存率仅为25%，对老年患者生命健康造成严重威胁［2］。因此，如何防治老年CHF显得尤为重要。本研究采用复方丹参滴丸联合坎地沙坦酯片治疗老年CHF取得满意疗效，现报道如下。……