应用小剂量泼尼松治疗亚急性甲状腺炎患者的临床效果

2016-10-19方轶群

中国现代医生 2016年24期

关键词：症状

黄　伟　方轶群

江西省景德镇市第一人民医院内分泌科，江西景德镇333000

应用小剂量泼尼松治疗亚急性甲状腺炎患者的临床效果

黄伟方轶群

江西省景德镇市第一人民医院内分泌科，江西景德镇333000

目的探讨亚急性甲状腺炎患者应用小剂量泼尼松治疗的临床效果。方法对2013年3月～2015年3月我院84例亚急性甲状腺炎患者的临床资料进行统计分析。结果比较患者治疗前后指标情况，治疗后观察组患者FT3（6.35±1.67）pmol/L、FT4（16.65±3.53）pmol/L、TSH（2.46±0.41）μIU/L与对照组患者FT3（6.22±1.45）pmol/L、FT4（17.87±3.99）pmol/L、TSH（2.40±0.42）μIU/L比较，差异无统计学意义（P＞0.05）；观察组患者治疗后发热、肿胀、疼痛、触痛症状消失时间均明显少于对照组患者，差异有统计学意义（P＜0.05）。观察组患者不良反应发生率（4.76%）明显低于对照组（28.57%），差异有统计学意义（χ2=8.57143，P=0.00341＜0.05）。结论小剂量泼尼松治疗亚急性甲状腺炎，患者发热、肿胀、疼痛、触痛症状消失时间明显缩短，不良反应发生率较低，安全、有效，建议临床广泛应用。

亚急性甲状腺炎；抗病毒治疗；小剂量泼尼松；不良反应

［Abstract］Objective To investigate the clinical effect of low-dose prednisone in the treatment of subacute thyroiditis. Methods The clinical data of 84 cases of patients with subacute thyroiditis in the hospital from March 2013 to March 2015 were statistically analyzed.Results The various indicators before and after treatment of the two groups were compared，after treatment，the observation group FT3（6.35±1.67）pmol/L，FT4（16.65±3.53）pmol/L，TSH（2.46±0.41）μIU/L compared with the the control group FT3（6.22±1.45）pmol/L，FT4（17.87±3.99）pmol/L，TSH（2.40±0.42）μIU/L had no significant changes，the differences were not significant（P＞0.05）；The duration of fever，swelling，pain，and tenderness of the observation group were significantly shorter than those of the control group（P＜0.05）.The incidence of adverse reactions of the observation group was 4.76%，which was obviously lower than that of the control group（28.57%），there was statistical significance（χ2=8.57143，P=0.00341＜0.05）.Conclusion Low-dose prednisone can shorten duration of clinical symptoms such as fever，swelling，pain，and tenderness.It is characterized by high effective，safe and low incidence of adverse reactions，which is recommended widely used.

［Key words］Subacute thyroiditis；Antiretroviral therapy；Low-dose prednisone；Adverse reactions

亚急性甲状腺炎属于一种自限性炎症疾病，该病的发生与病毒感染和自身内分泌调节功能紊乱有关，但其发病机制尚未明确［1］。小剂量泼尼松治疗亚急性甲状腺炎疗效确切，为进一步探讨亚急性甲状腺炎患者应用小剂量泼尼松治疗的临床效果，特选取我院84例亚急性甲状腺炎患者作为研究对象，现报道如下。