张利霞　张中平　许丽娟

江苏省常州市武进人民医院消化内科，江苏常州213003

IL-23和PG-1水平在不同胃部疾病患者体内的临床表达意义

张利霞张中平▲许丽娟

江苏省常州市武进人民医院消化内科，江苏常州213003

目的分析白细胞介素-23和胃蛋白酶原-1水平在不同胃部疾病患者体内的临床表达意义，为不同胃部疾病的早期鉴别提供参考依据。方法以187例胃部疾病患者为研究对象，按其诊断结果进行分组，检测患者胃组织IL-23表达及血清IL-23、PG-1表达，分析其相关性及临床表达意义。结果CAG组病变组织IL-23水平高于CSG组，GC组病变组织IL-23水平高于CAG组（P＜0.05）；CSG组织中IL-23为弱阳性表达，而CAG、GC组织中IL-23均为强阳性表达。CAG组血清IL-23水平高于CSG组，GC组血清IL-23水平高于CAG组（P＜0.05）；CAG组血清PG-1水平低于CSG组，GC组血清PG-1水平低于CAG组，差异有统计学意义（P＜0.05）。CSG组（r=-0.470）、CAG组（r=-0.524）、GC组（r=-0.751）患者血清IL-23与PG-1均呈负相关（P＜0.05）。结论随着胃部疾病的进展，患者病变组织及血清IL-23水平逐渐升高，血清PG-1水平逐渐降低，根据患者病变组织及血清IL-23变化及IL-23/PG-1比值有望提高胃癌及癌前病变的早期检出率。

白细胞介素-23；胃蛋白酶原-1；胃部疾病；胃癌；鉴别

［Abstract］Objective To analyze the significance of clinical expression of interleukin 23（IL-23）and pepsinogen 1（PG-1）in the patients with different gastric diseases，so as to provide references for the early identification of different gastric diseases.Methods 187 patients with gastric diseases were selected as research subjects.According to their diagnostic results，the patients were assigned to groups.IL-23 expression and serum IL-23 and PG-1 expression in the gastric tissues in the patients were tested，and their relevance and significance of clinical expression were analyzed. Results IL-23 level of the pathological tissues in the CAG group was higher than that in the CSG group，and IL-23 level of the pathological tissues in the GC group was higher than that in the CAG group（P＜0.05）；the expression of IL-23 in the CSG tissues was weakly positive，and the expression of IL-23 in CAG and GC tissues was strongly positive. Serum IL-23 level in CAG group was higher than that in the CSG group，and serum IL-23 level in the GC group was higher than that in the CAG group（P＜0.05）；serum PG-1 level in the CAG group was lower than that in the CSG group，and serum PG-1 level in the GC group was lower than that in the CAG group.The differences were statistically significant（P＜0.05）.Serum IL-23 was negatively correlated with PG-1 in the patients in CSG group（r=-0.470），CAG group（r=-0.524）and GC group（r=-0.751）（P＜0.05）.Conclusion With the progression of gastric diseases，IL-23 levels in the pathological tissues and serum in the patients are gradually increased，and the serum PG-1 level was gradually reduced.According to the changes of pathological tissues and serum IL-23，as well as IL-23/PG-1 ratio，early detection rate of gastric cancer and precancerous lesion is expected to be increased.

［Key words］Interleukin 23（IL-23）；Pepsinogen 1（PG-1）；Gastric diseases；Gastric cancer；Identification

胃癌（gastric cancer，GC）是临床常见的消化道恶性肿瘤，具有发病率高、早期诊断困难等特征，若能够得到早期诊断与及时治疗，95%以上患者可得到治愈，但目前我国GC早期诊断率不足10%，多数患者确诊时已失去最佳治疗时机［1］。胃镜活检是诊断GC的“金标准”，但其创伤大、费用昂贵且早期诊断价值较低，临床推广受限［2］。近年来，胃蛋白酶原-1（pepsinogen 1，PG-1）、白细胞介素-23（interleukin 23，IL-23）在各类胃部疾病的鉴别及GC的早期筛查中得到了广泛关注［3］。……