卢湧湧　黄　航　李　鹏　武志刚　吴秀玲

1.温州医科大学附属第一医院泌尿外科，浙江温州325000；2.温州医科大学附属第一医院病理科，浙江温州325000

5α还原酶抑制剂对前列腺增生组织内雌激素受体、雄激素受体表达的影响

卢湧湧1黄航1李鹏2武志刚1吴秀玲2

1.温州医科大学附属第一医院泌尿外科，浙江温州325000；2.温州医科大学附属第一医院病理科，浙江温州325000

目的研究5α还原酶抑制剂（5α-RI）对良性前列腺增生（BPH）患者前列腺组织内雄激素受体（AR）、雌激素受体α（ERα）、雌激素受体β（ERβ）表达的影响。方法选择100例BPH患者随机分为4组，每组25例，对照组口服维生素C 0.1 g，1次/d，非那雄胺组口服非那雄胺5 mg，1次/d，度他雄胺组口服度他雄胺治疗0.5 mg，1次/d，依立雄胺组口服依立雄胺5 mg，2次/d，治疗8周后行经尿道前列腺电切术，采用免疫组化方法观察术后前列腺组织内AR、ERα、ERβ的表达情况。结果采用IHS法对免疫组化结果进行半定量分析，其中AR表达方面，对照组（10.36±1.63）、非那雄胺组（9.08±1.71）、度他雄胺组（9.12±2.42）、依立雄胺组（7.92±2.36）之间差异有统计学意义（P＜0.05），且依立雄胺组下降更为显著。ERα表达各组间变化不明显。与对照组ERβ表达（5.24±1.20）比较，度他雄胺组（6.52±1.57）、依立雄胺组（6.76±1.55）表达显著增强，非那雄胺组（5.60±1.04）表达有所增强，但差异无统计学意义（P＞0.05）。结论5α-RI可抑制BPH患者前列腺组织内的AR表达，增强ERβ表达，对ERα表达影响不大，不同5α-RI对AR、ERα、ERβ表达的影响程度有差异。

5α还原酶抑制剂；雌激素受体；雄激素受体；前列腺增生

［Abstract］Objective To explore the effects of 5α reductor inhibitors（5α-RI）on the expression of androgen receptor，estrogen receptor α（ERα）and estrogen receptor β（ERβ）in the prostatic tissues in the patients with benign prostatic hyperplasia（BPH）.Methods A total of 100 patients with BPH were randomly assigned to four groups，with 25 patients in each group.The control group was orally given vitamin C of 0.1 g，once a day.Finasteride group was orally given finasteride of 5 mg，once a day.Dutasteride group was orally given dutasteride of 0.5 mg，once a day.Epristeride group was orally given epristeride of 5 mg，twice a day.Prostate electrocision was performed via urethra 8 weeks after the treatment，and the expression of AR，ERα，and ERβ in the prostatic tissues was observed after the surgery via immunohistochemistry.Results IHS method was applied to conduct semi-quantitative analysis on the results of immunohistochemistry.There were significant differences of AR expression between the control group（10.36±1.63），finasteride group（9.08±1.71），dutasteride group（9.12±2.42）and epristeride group（7.92±2.36），and the reduction in epristeride group was more significant（P＜0.05）.There were not significant changes of ERα expression between each group.The expression of ERβ in dutasteride group（6.52±1.57）and epristeride group（6.76±1.55）was significantly enhanced compared with that in the control group（5.24±1.20），and the expression in finasteride group（5.60±1.04）was enhanced，but there were no statistically significant differences（P＞0.05）.Conclusion 5α-RI is able to inhibit AR expression and enhance ERβ expression in the prostatic tissues in the patients with BPH.It does not have great effects on the expression of ERα.Different 5α-RIs have different effects on the expression of AR，ERα and ERβ.

［Key words］5α Reductor inhibitors（5α-RI）；Estrogen receptor；Androgen receptor；Prostatic hyperplasia良性前列腺增生（benign prostatic hyperplasia，BPH）是老年男性常见病，其发病机制尚不十分清楚，比较明确的两个必要条件是有功能的睾丸和年龄的增长。……