高　丹

辽宁省东港市中医院肝病科，辽宁东港118300

氧化苦参碱联合拉米夫定对慢性乙型肝炎患者血清IL-2、IL-4、IL-10水平的影响

高丹

辽宁省东港市中医院肝病科，辽宁东港118300

目的探讨氧化苦参碱联合拉米夫定对慢性乙型肝炎患者血清IL-2、IL-4、IL-10水平的影响。方法选择2014年1月～2015年6月在我院治疗的慢性乙型肝炎患者60例的临床资料进行回顾性分析。其中30例患者采用拉米夫定治疗为对照组，另外30例患者在此基础上给予氧化苦参碱治疗为研究组。比较两组的临床疗效、血清IL-2、IL-4、IL-10水平。结果研究组HBV应答率、HBV-DNA转阴率、HBeAg转阴率显著高于对照组（P＜0.05），HBV-YMDD变异率显著低于对照组，差异有高度统计学意义（P＜0.01）。研究组临床疗效显著优于对照组，差异有统计学意义（P＜0.05）。两组治疗后，IL-2水平较治疗前显著升高，IL-4、IL-10水平较治疗前显著下降，差异有高度统计学意义（P＜0.01）。治疗后，研究组患者IL-2水平显著高于对照组，IL-4、IL-10水平显著低于对照组，差异有高度统计学意义（P＜0.01）。结论联合氧化苦参碱及拉米夫定治疗慢性乙型肝炎能够显著改善临床疗效，改善患者血清炎性因子水平。

氧化苦参碱；拉米夫定；慢性乙型肝炎；血清炎性因子

［Abstract］Objective To discuss the effect of Matrine oxide combined with Lamivudine on IL-2，IL-4，IL-10 for Chronic hepatitis B.Methods Clinical data of 60 cases with Chronic hepatitis B from Jan 2014 to Jun 2015 were respectively analyzed.30 cases of control group weretreated with Lamivudine，and 30 cases of study group were treatedwith Matrine oxide combined with Lamivudine.Clinical efficacy，IL-2，IL-4 and IL-10 levels of two groups were compared.Results The HBV response rate，HBV-DNA negative rate and HBeAg negative conversion rate of study group were higher than that in the control group，and HBV-YMDD mutation rate was lower than that in the control group（P＜0.05 or＜0.01）.Total effective rate of study group was higher than that in the control group（P＜0.05）.After treatment，IL-2 levels of two groups were higher than before treatment，and IL-4 and IL-10 levels of two groups were lower than before treatment（P＜0.01）.After treatment，IL-2 level of study group was higher than that in the control group，and IL-4 and IL-10 levels of study group were lower than that in the control group（P＜0.01）.Conclusion Matrine oxide combined with Lamivudine for Chronic hepatitis B can improve clinical efficacy，and the level of serum inflammatory factors.

［Key words］Matrine oxide；Lamivudine；Chronic hepatitis B；Serum inflammatory factors

乙肝病毒对肝细胞反复损伤，发展为重症肝炎，最终发展为肝硬化甚至肝癌，造成不良预后［1］。慢性乙型肝炎病情发展过程中，炎性因子发挥了重要的作用。拉米夫定是临床上常用的治疗慢性乙型肝炎的药物，属于抗病毒药物。但长期用药，有一定的耐药性，并且容易复发［2，3］。氧化苦参碱是从生物碱中提取的活性成分，能够抑制乙肝病毒的复制，抗肝纤维化。……