钟燕华　皮厚远

中医辨证联合莫西沙星、柳氮磺吡啶治疗溃疡性结肠炎效果观察

钟燕华皮厚远

目的探讨中医辨证联合莫西沙星、柳氮磺吡啶治疗溃疡性结肠炎的临床疗效。方法选取116例溃疡性结肠炎患者随机分为实验组和对照组，实验组给予中医辨证联合莫西沙星、柳氮磺吡啶治疗，对照组给予莫西沙星、柳氮磺吡啶治疗，比较两组患者临床疗效、临床症状消失时间、治疗前后炎症水平及治疗过程中的不良反应发生情况。结果实验组的临床总有效率为96.55%，显著高于对照组的77.59%；实验组腹痛消失时间、便血消失时间较对照组均显著缩短；治疗后实验组IL-6水平较对照组显著下降，IL-13水平较对照组显著升高，差异均具有统计学意义（P＜0.05）；实验组不良反应发生率为8.62%，对照组不良反应发生率为5.17%，两组不良反应发生率差异无统计学意义（P＞0.05）。结论中医辨证治疗联合莫西沙星、柳氮磺吡啶治疗溃疡性结肠炎临床疗效显著提高，临床症状消失时间缩短，炎症因子水平改善，且安全性较高，值得进一步在临床上推广。

中医辨证；莫西沙星；柳氮磺吡啶；溃疡性结肠炎

【Abstract】Objective To evaluate the efficacy of Chinese dialectical therapy combined with moxifloxacin and sulfasalazine on patients with ulcerative colitis.Methods One hundred and sixteen patients with ulcerative colitis were randomly divided into experimental and control groups.Experimental group received Chinese dialectical therapy combined with moxifloxacin and sulfasalazine，while control group received moxifloxacin and sulfasalazine treatment.The efficacy，disappearance time of clinical symptoms，the serum level of inflammatory cytokines and adverse reactions during treatment in two groups was compared.Results The effective rate in experimental group（96.55%）was significantly higher than that in control group（77.59%）.The duration of abdominal pain and bloody stool in experimental group was significantly shorter than that in the control group.Compared with control group，the serum level of IL-6 in experimental group was significantly decreased，while the serum level of IL-13 was significantly increased（P＜0.05）.The adverse reaction rates in experimental group and control group were 8.62%and 5.17%，respectively（P＞0.05）.Conclusion Chinese medicine dialectical therapy combined with moxifloxacin and sulfasalazine significantly improved clinical efficacy，shortened the time of clinical symptoms and improved the levels of inflammatory cytokines of patients with ulcerative colitis.It is a quiet safe and effective therapy for patients with ulcerative colitis.

【Key words】Chinese dialectical therapy；Moxifloxacin；Sulfasalazine；Ulcerative colitis

溃疡性结肠炎（ulcerative colitis，UC）是一种病因尚不十分清楚的结肠和直肠慢性非特异性炎症性疾病，病变局限于大肠黏膜及黏膜下层，多位于乙状结肠和直肠，也可延伸至降结肠，甚至整个结肠，病程漫长，常反复发作［1］。由于该病的发病机制尚不清楚，临床上治疗起来具有一定的难度。目前临床上主要采用糖皮质激素、水杨酸抑制剂、免疫抑制剂等药物进行治疗，但是治疗效果不显著，且容易产生依赖性［2］。……