胡春

(四川省中医药高等专科学校妇产科，四川 绵阳　621000)



达英-35和妈富隆对多囊卵巢综合征高雄激素血症的治疗疗效以及对卵泡发育的影响

胡春

(四川省中医药高等专科学校妇产科，四川 绵阳621000)

目的：对比分析达英-35和妈富隆对多囊卵巢综合征高雄激素血症的治疗疗效及对卵泡发育的影响。方法：将2013年5月至2015年5月本院收治的86例多囊卵巢综合征患者随机分为妈富隆组和达英-35组，分别采用妈富隆和达英-35连续治疗3个疗程。比较两组患者治疗前后体重指数、腰臀比、多毛、痤疮症状和主要性激素(FSH、LH、T)水平的变化以及卵泡发育情况。结果：两组患者治疗后体重指数、腰臀比均比治疗前降低，差异无统计学意义(P>0.05)；多毛评分、痤疮评分、LH和T激素水平较治疗前降低(P<0.05)，但妈富隆组的FSH水平较治疗前升高；达英-35组患者卵泡发育治愈率(37.21% vs.23.26%)和总有效率(88.37% vs.69.76%)均高于妈富隆组(P<0.05)。结论：妈富隆与达英-35均能有效治疗多囊卵巢综合征高雄激素血症，但达英-35对多囊卵巢综合征患者卵泡发育的改善效果更加显著。

达英-35；妈富隆；多囊卵巢综合征；高雄激素血症

【Abstract】Objective：Compare the effects of Diane-35 and Marvelon on treatment of hyperandrogenemia and follicular development in patients with polycystic ovary syndrome.Methods：Eighty-six patients with polycystic ovary syndrome treated in our hospital during May 2013 and May 2015 were divided into Diane-35 group and Marvelon group.Diane-35 group was treated with Diane-35 and Marvelon group was treated with Marvelon for three courses respectively.The clinical effects such as body index,waist-hip ratio,hirsutism and acne were compared.The follicular development and the level of sex hormone FSH,LH and T were also recorded.Results：After treatment,the body index,waist-hip ratio were decreased but with no statistical significance.There were statistical significance in the level of FSH,LH,T,as well as the scores of hirsutism and acne between the two groups (P<0.05).Additionally,the curative rate and total effective rate of follicular development in Diane-35 group were much higher than that of Marvelon group (P<0.05).Conclusion：Both Diane-35 and Marvelon had effects on hyperandrogenemia in patients with polycystic ovary syndrome,but Diane-35 had better improvement on clinical symptoms and level of FSH,LH and T than that of Marvelon.

多囊卵巢综合征(polycystic ovary syndrome,PCOS)是一种常见的妇科内分泌疾病，其主要的临床特点为月经不规则、排卵障碍、高雄激素血症、生殖功能障碍及胰岛素抵抗[1-2]。口服避孕药是治疗PCOS 的一线药物，能降低患者血清黄体生成素(LH)、睾酮(T)水平，改善多毛、痤疮等临床症状[3-4]。达英-35和妈富隆是临床治疗多囊卵巢综合征的常用药物，可有效改善此病患者的内分泌紊乱及临床症状。笔者对两种药物对PCOS患者高雄激素血症的治疗效果及其对生殖的影响进行了对比研究，现将结果报告如下。

1　材料与方法

1.1临床资料

选取2013年5月至2015年5月本院收治的年龄在16～41岁、确诊为多囊卵巢综合征的患者86例为研究对象，并随机分为观察组和对照组，每组各43例。入……