蒋红，杜华英，贾艾敏，姚亚希，杨明辉,4

(川北医学院附属医院，1.风湿免疫研究所；2.医学研究中心；3.烧伤科；4.检验科，四川 南充　637000)



化疗药物渗漏性损伤治疗新方法的临床应用及相关机理

蒋红1,2，杜华英3，贾艾敏2，姚亚希2，杨明辉1,2,4

(川北医学院附属医院，1.风湿免疫研究所；2.医学研究中心；3.烧伤科；4.检验科，四川 南充637000)

目的：探讨化疗药物渗漏性损伤治疗新方法的临床应用及相关机理。方法：随机抽取本院2012年3月至2015年3月肿瘤科化疗药物渗漏性损伤患者100例为研究对象，随机分为两组，每组50例，对照组使用2%山莨菪碱进行局部封闭治疗后50%MgSO4持续加压冷敷1 d后热敷，观察组使用2%山莨菪碱联合1%利多卡因进行局部封闭治疗后50%MgSO4持续加压冷敷1 d后热敷，观察比较两组临床应用效果。结果：观察组治疗总有效率显著高于对照组，皮肤损伤愈合时间显著短于对照组，差异比较具有统计学意义。结论：2%山莨菪碱联用1%利多卡因能有效治疗化疗药物渗漏性损伤，值得临床推广应用。

化疗药物；渗漏性损伤；治疗方法；机理

【Abstract】Objective：To evaluate the clinical application and related mechanism of new treatments for chemotherapy extravasation injury.Methods：100 cases of oncology patients with chemotherapy extravasation injury who were hospitalized during March 2012 and March 2015,were randomly divided into two groups.50 patients in the control group were given 2% anisodamine for local closure therapy while patients in the observation group were given 2% anisodamine combined with 1% lidocaine.All the patients were given cold compress with sustained pressure for 1 day and subsequently hot compress.50% MgSO4was used both in the cold compress and the hot compress.The clinical effect was observed between the two groups.Results：The total effective rate of observation group was significantly higher than that of the control group,the time of skin wound healing was significantly shorter than that of the control group,the difference was statistically significant.Conclusion：2% anisodamine combined with 1% lidocaine can effectively treat chemotherapy extravasation injury.This therapy is worthy of clinical application and application.

【Key words】Chemotherapy;Extravasation injury;Treatment;Mechanism

静脉输注化疗药物是各种综合治疗恶性肿瘤的重要手段之一，但化疗药物大多刺激性很强，在输注过程中渗出或渗漏到皮下可导致不同程度的组织损伤，称为渗漏性损伤[1-2]。造成渗漏性损伤的因素很多，主要与药物酸碱度、渗透压、药物浓度、药物本身的毒性作用及Ⅰ型变态反应有关，临床表现为轻者引起局部肿胀、疼痛，重者引起周围组织坏死，甚至造成功能障碍等[3]。……