雍桂珍，兰长骏，甘宇业

(川北医学院附属医院眼科,四川 南充　637000)



LASIK术后干眼与非干眼症状患者的影响因素比较研究

雍桂珍，兰长骏，甘宇业

(川北医学院附属医院眼科,四川 南充637000)

目的：评价LASIK术后6个月干眼症状相关的影响因素。方法：随访LASIK手术后6个月，360例患者根据是否有干眼症状分成干眼症状组和非干眼症状组。比较两组间干眼症状和SPEED评分，χ2检验和t检验用于统计分析。结果：干眼症状组与非干眼症状组比较：长时间用眼阅读、睡眠差、紧张、认为干眼与手术有关的比例分别为(30.5% vs.12.5%，P=0.000)、(18.3% vs.9.6%，P=0.025)、(24.4% vs.9.9%，P=0.002)、(35.4% vs.1.5%，P=0.000)；干眼症状组有、无相关影响因素SPEED评分分别为(3.22±1.72)vs.(1.92±1.57)，P=0.001；(2.62±1.52)vs.(1.82 ±1.45)，P=0.045；(2.72±1.57)vs.(1.98±1.39)，P=0.043；(3.02±1.66)vs.(1.88±1.47)，P=0.032。两组间饮酒和吸烟无统计学意义。结论：干眼症状组患者更容易发生长时间用眼阅读、睡眠差、紧张及认为干眼与手术有关等情况。本研究利于合理解释LASIK术后远期干眼的症状和提高相关治疗。

准分子激光原位角膜磨镶术；干眼；影响因素

【Abstract】Objective：To evaluate the influencing factors associated with the symptoms of dry eye after laser-assisted in situ keratomileusis(LASIK)surgery at postoperative 6 months.Methods：At follow-up after postoperative 6 months,360 patients were divided into dry eye symptoms and no dry eye symptoms groups according to whether they had dry eye symptoms,dry eye symptoms and SPEED scores were compared between two groups.Chi-square and t test were performed for statistical analysis．Results：In the dry eye symptoms and no dry eye symptoms groups reading for long time,poor sleeping,stress,considering dry eye symptoms associated with operation occurred(30.5% vs.12.5%,P=0.000)，(18.3% vs.9.6%，P=0.025)，(24.4% vs.9.9%,P=0.002)，(35.4% vs 1.5%，P=0.000),respectively.In the dry eye symptoms group patients with or without influencing factors SPEED scores were(3.22±1.72 vs.1.92±1.57,P=0.001),(2.62±1.52 vs.1.82 ±1.45,P=0.045),(2.72±1.57 vs.1.98±1.39,P=0.043),(3.02±1.66 vs.1.88±1.47,P=0.032),respectively． No significant differences were observed in drinking,smoking habit between two groups.Conclusion：Reading for long time,poor sleeping,stress,considering dry eye symptoms associated with operation occurred more easily in dry eye symptoms group patients．These results may be helpful to explain further dry eye and improve related treatments after LASIK surgery.

【Key words】Laser-assisted in situ keratomileusis；Dry eye；Influencing factors

矫治近视手术的准分子激光原位角膜磨镶术(laser-assisted in situ keratomileusis，LASIK)已在临床中成熟应用，安全有效，一些患者术后会出现眼部异物感、干涩感、不适感、烧灼感等干眼症状[1-2]，这可能引起视力波动，也可能影响工作效率[3]。因此，LASIK术后常规给予人工泪液单独应用或者联合应用以缓解干眼症状[4]，但临床上一般3个月后随手术恢复后多数患者干眼症状缓解，无需再用人工泪液。临床中观察发现部分患者术后较长时间仍有干眼症状，LASIK术3个月后干眼症状的相关影响因素文献报告较少，现在总结82例LASIK术后6个月有干眼症状患者与非干眼症状患者的对比研究如下。……