袁橙齐齐哈尔医学院药学院，黑龙江齐齐哈尔　161006

盐酸氯丙嗪凝胶处方优化及质量评价方法在药剂实验课中的实施

袁橙
齐齐哈尔医学院药学院，黑龙江齐齐哈尔161006

目的 探讨使学生在药剂实验课课堂掌握处方设计及质量评价的方法。方法 以盐酸氯丙嗪为主药，学生分组对盐酸氯丙嗪凝胶剂进行处方筛选及质量评价。首先利用筛选出的羧甲基纤维素钠为凝胶基质，对基质用量进行了筛选，然后对透皮吸收促进剂丙二醇、氮酮及薄荷脑的用量也进行了筛选，筛选过程均采用体外经皮渗透实验，计算累积释放百分率。利用筛选出的最佳处方制备了盐酸氯丙嗪凝胶剂，并对质量标准进行了考察。结果 学生筛选出的制备盐酸氯丙嗪凝胶剂的最佳处方为羧甲基纤维素钠基质用量为4%，透皮吸收促进剂氮酮和薄荷脑合用含量都为3%，以最佳处方制备的盐酸氯丙嗪凝胶剂符合质量标准。结论 学生通过这种方法在实验课堂上又快又准地掌握处方优化与质量评价的方法。建议可以推广到其他课程的教学中。

盐酸氯丙嗪；凝胶基质；透皮吸收促进剂；分组操作

［Abstract］Objective To make the students master the formulation design and quality evaluation method in the pharmacy experiment class.Methods The chlorpromazine hydrochloride gel agents were given the formulation screening and quality evaluation by the students divided into groups taking the chlorpromazine hydrochloride as the main drug，the substrates quantity was screened by the gel stroma that was the sodium carboxymethyl cellulose screened，and then the dosages of penetration enhancer such as propylene glycol，azone and menthol were screened，the screening course adopted the in vitro transdermal penetration experiment，the cumulative release percent was calculated，the chlorpromazine hydrochloride gel agent was prepared by the best prescription screened out，and the quality standards were examined.Results The substrates quantity of sodium carboxymethyl cellulose which was the best prescription of preparing chlorpromazine hydrochloride gel agent screened out by students was 4%，the combined content of penetration enhancers such as azone and menthol was 3%，and the chlorpromazine hydrochloride gel agent prepared by the best prescription met the quality standards.Conclusion Students can rapidly and accurately master the formulation optimization and quality evaluation method in the experimental class in this way，and it is suggested to be promoted in the teaching of other courses.

［Key words］Chlorpromazine hydrochloride；Gel stroma；Penetration enhancer；Grouping operation

盐酸氯丙嗪是抗精神病药物中具有代表性的药物之一［1］。其主要作用机制不仅能阻断α肾上腺素受体，还能阻断M胆碱受体［2］。该药口服吸收不仅慢而且没有规则，易受剂型、胃内容物、合用药物的影响，使其生物利用度较低，需要较大量使用，且精神病人由于特殊的心理，往往拒绝服药；……