黄　莉　刘桂英　李　明（.北京安贞医院，北京 00029；2.首都医科大学中医药学院，北京 00069）



小儿喘宝辅助控制儿童支气管哮喘外寒内热证临床研究*

黄莉1刘桂英1李明2△
（1.北京安贞医院，北京 100029；2.首都医科大学中医药学院，北京 100069）

目的 研究小儿喘宝辅助控制儿童支气管哮喘外寒内热证的有效性和安全性。方法 将66例儿童支气管哮喘患儿，按随机对照单盲的研究方法分为实验组对照组，对照组予吸入布地奈德混悬液1 mg，每日1次，口服孟鲁司特钠5 mg，每日1次，实验组同时予小儿喘宝6～12 g/d。两组疗程均为12周。观察哮喘控制及中医证候疗效。结果 实验组哮喘控制率76.67%，高于对照组的56.67%（P＜0.05）；中医证候疗效实验组有效率90.00%，与对照组70.00%比较，差异有统计学意义（P＜0.05）；中医证候积分实验组治疗后积分与本组治疗前比较，与对照组治疗后比较，差异均有统计学意义（P＜0.05）；治疗结束随访12周，实验组哮喘复发率14.29%，对照组复发率50.00%。实验期间两组均未发现不良反应。结论 小儿喘宝辅助控制儿童支气管哮喘，临床疗效确切，复发率低，使用安全。

儿童支气管哮喘小儿喘宝中医辨证

【Abstract】Objective：To explore the clinical effect and safety of Xiaoer Chuanbao on bronchial asthma in children with the syndrome of external cold andinterior heat.Methods：66 cases of bronchial asthma in children were randomly divided into the treatment group and the control group，using parallel control and single-blind clinical trial methods.The control group were treated with Budesonide 1mg per day and Montelukast 5mg per day.At the same time，the treatment group were treated with Xiaoer Chuanbao 6～12 g per day.The clinical effect was observed in 12 weeks for a course of treatment.Results：After treatment，the control rate of asthma in the treatment group（76.67%）was higher than that of the control group（56.67%），which had a significant difference（P＜0.05）. TCM syndrome efficacy rate of the treatment group（90.00%）was higher than that of the control group（70.00%），which had a significant difference（P＜0.05）.TCM syndrome score of the treatment group was significantly different from that of the control group（P＜0.05）.And In the follow-up of 12 weeks after treatment，the recurrence rate of the treatment was 14.29%，the control group 50.00%.No adverse reactions were found in the two groups during the experiment.Conclusion：The clinical effect of Xiaoer Chuanbao in curing bronchial asthma in children is significant with a low recurrence rate and safety.

【Key words】Bronchial asthma in children；Xiaoer Chuanbao；TCM differentiation

近年来随着对哮喘认识的不断深入，儿童哮喘的总体治疗状况较前有明显提高，但仍存在许多不尽人意之处。第2次亚太儿童哮喘现状研究结果显示，虽然就疾病严重度而言，我国儿童哮喘以间歇发作为主，但与亚太其他国家和地区相比，我国儿童哮喘的控制水平仍较低，绝大多数患儿家长认为患儿的哮喘并未得到良好控制［1］。现代医学对儿童支气管哮喘的主要治疗原则是抗炎，目前药物治疗仍是最有效方法，以糖皮质激素为主。……