蒋允丽+孟勇+孙健+姚萍

【摘要】 目的 探讨多种益生菌联合芦荟珍珠胶囊治疗老年人便秘型肠易激综合征的临床疗效。方法 60例老年便秘型肠易激综合征患者， 随机分为对照组A组、对照B组和治疗组， 各20例。对照A组给予口服枯草杆菌二联活菌肠溶胶囊及双歧杆菌三联活菌胶囊治疗， 对照B组给予芦荟珍珠胶囊治疗， 治疗组给予枯草杆菌二联活菌肠溶胶囊、双歧杆菌三联活菌胶囊及芦荟珍珠胶囊治疗。比较三组的临床疗效及不良反应。结果 对照A组、对照B组及治疗组治疗2周时总有效率分别为20%、25%、50%；治疗4周时分别为30%、55%、95%；停药2周时分别为25%、35%、95%。治疗组总有效率于治疗2周、治疗4周及停药2周时均明显高于对照A组及对照B组 （P<0.05）。三组不良反应发生率比较， 差异无统计学意义（P>0.05）。结论 枯草杆菌二联活菌肠溶胶囊、双歧杆菌三联活菌胶囊联合芦荟珍珠胶囊治疗老年人便秘型肠易激综合征疗效确切， 复发率低， 不良反应发生率低。

【关键词】 益生菌；枯草杆菌二联活菌肠溶胶囊；双歧杆菌三联活菌胶囊；芦荟珍珠胶囊；便秘型肠易激综合征

DOI：10.14163/j.cnki.11-5547/r.2016.21.001

【Abstract】 Objective To investigate clinical effect by multiple probiotics combined with aloe pearl capsule in the treatment of senile constipation-predominant irritable bowel syndrome. Methods A total of 60 senile constipation-predominant irritable bowel syndrome patients were randomly divided into control group A， control group B and treatment group， with 20 cases in each group. Control group A received oral administration of bacillus subtilis duplex living bacterium enteric capsule combined with bifidobacterium triple living bacterium capsule， control group B received aloe pearl capsule for treatment， and treatment group received bacillus subtilis duplex living bacterium enteric capsule， bifidobacterium triple living bacterium capsule and aloe pearl capsule for treatment. Clinical effects and adverse reactions were compared in the three groups. Results In 2 weeks of treatment， control group A， control group B and treatment group had effective rates respectively as 20%， 25% and 50%， which were 30%， 55% and 95% in 4 weeks of treatment and 25%， 35% and 95% in 2 weeks after drug withdrawal. The treatment group had obviously higher effective rates in 2 and 4 weeks of treatment and 2 weeks after drug withdrawal than control group A and control group B （P<0.05）. There was no statistically significant difference of incidence of adverse reactions across the three groups （P>0.05）. Conclusion Combination of bacillus subtilis duplex living bacterium enteric capsule， bifidobacterium triple living bacterium capsule and aloe pearl capsule provides precise effect in treating senile constipation-predominant irritable bowel syndrome， along with low recurrence rate and incidence of adverse reactions.

【Key words】 Probiotics； Bacillus subtilis duplex living bacterium enteric capsule； Bifidobacterium triple living bacterium capsule； Aloe pearl capsule； Constipation-predominant irritable bowel syndrome

肠易激综合征（irritable bowel syndrome， IBS）是一类腹痛、腹胀、不适， 与排便相关并伴有排便习惯和粪便性状改变的功能性肠道疾病， 其特征是肠道壁无器质性病变。其中， 老年人便秘型肠易激综合征临床上较常见， 但单一用药治疗此病效果差， 且易复发， 现探讨联合用药疗效， 报告如下。

1 资料与方法

1. 1 一般资料 选择2012年8月～2014年2月本院消化内科门诊60例老年便秘型肠易激综合征患者， 符合罗马Ⅲ标准[1]。其中男28例， 女32例， 年龄60～85岁， 平均年龄72.5岁， 病程1～10年， 就诊时发病， 排便周期每3～15天1次， 既往无抑郁、焦虑等精神症状。……