刘成功，李万森，杨小东，田艳娟，高大红驻马店市中心医院综合内科，河南驻马店　463000

莫沙比利联合胃肠起搏治疗糖尿病胃轻瘫临床效果分析

刘成功，李万森，杨小东，田艳娟，高大红
驻马店市中心医院综合内科，河南驻马店463000

目的研究莫沙比利联合胃肠起搏治疗糖尿病胃轻瘫临床效果。方法试验对象：该院近年来收治的83例糖尿病胃轻瘫患者。患者分组方法：随机数字表法。83例患者分为药物组和药物+起搏组两个组别。药物组以莫沙比利进行治疗；药物+起搏组以莫沙比利联合胃肠起搏进行治疗。观察指标：①总有效率；②治疗前和治疗后患者胃排空时间、消化道症状积分的差异；③不良表现。结果①药物+起搏组相比于药物组总有效率更高，差异有统计学意义（P＜0.05）。②治疗前两组胃排空时间、消化道症状积分相似，差异无统计学意义（P＞0.05）；治疗后药物+起搏组相比于药物组胃排空时间、消化道症状积分改善更显著，差异有统计学意义（P＜0.05）。③两组有个别患者轻微腹泻和口干，停药后消失，差异无统计学意义（P＞0.05）。结论莫沙比利联合胃肠起搏治疗糖尿病胃轻瘫临床效果确切，可有效加速胃排空，减轻消化道症状，值得推广。

莫沙比利；胃肠起搏；糖尿病胃轻瘫；临床效果

［Abstract］Objective To study the mo sand Billy with gastrointestinal pacemaker therapy of diabetic gastroparesis clinical effect.Methods The test object：of 83 patients admitted in our hospital in recent years in patients with diabetic gastroparesis.Grouping method：patients with random number table method.83 patients were divided into drugs and drug+pacemaker group two groups.Drug treatment group with mo sand Billy，Drug+pacemaker moser Billy joint group to gastrointestinal pacemaker for treatment.Observation indexes：①the total effective rate；②before and after treatment in patients with gastric emptying time，enteron symptom integral difference；③the bad performance.Results①Drug+pacemaker group compared with the drugs group total effective rate is higher，χ2test statistically significant（P＜0.05）；②the two groups before treatment，digestive tract symptoms integral，gastric emptying time t test statistical difference was not significant（P＞0.05）；Drug+pacemaker after drug treatment group than in drug group and gastric emptying time，improve the digestive tract symptoms integral，more prominent，t test statistical significant difference（P＜0.05）.③two groups of individual patients with mild diarrhea and dry mouth，disappeared after the drug was stopped，no significant difference（P＞0.05）.Conclusion Mosand Billy with gastrointestinal pacemaker therapy of diabetic gastroparesis clinical effect is precise，which can effectively accelerate gastric emptying，alleviate digestive tract symptoms，is worth promoting.

［Key words］Moser Billy；Gastrointestinal pacemaker；Diabetic gastroparesis；Clinical effect

［作者简介］刘成功（1980.2-），男，河南汝南人，硕士，主治医师，研究方向：内分泌与代谢病。

糖尿病胃轻瘫为糖尿病常见神经系统并发症，患者以胃动力出现障碍，胃排空延迟为主要表现，是因自主神经病变所致，目前临床治疗糖尿病胃轻瘫尚无特效药物，主要采用莫沙必利、吗丁啉等药物治疗，但单用效果欠佳，且容易反复［1］。……