二甲双胍在2型糖尿病治疗中的应用效果观察

2016-08-02罗华彬

中国卫生标准管理 2016年11期

罗华彬　

罗华彬

【摘要】目的探讨2型糖尿病治疗中应用二甲双胍的效果。方法随机抽取我社区中心门诊接诊的采取二甲双胍治疗的2型糖尿病患者50例进行研究，均进行3个月以上的治疗观察与随访，观察记录治疗前、治疗4周、12周时空腹血糖、餐后2 h血糖、糖化血红蛋白，以及治疗期间不良反应，并采取统计学分析。结果50例患者均顺利完成治疗，随着治疗时间增加，空腹血糖、糖化血红蛋白以及餐后2 h血糖均有改善，其中治疗12周时优于治疗前（P＜0.05）；50例患者治疗期间仅在服药1～2周出现不良反应7例，但持续时间短，随后自动缓解。结论二甲双胍应用在2型糖尿病中不仅可以改善血糖与血脂指标，而且安全性高。

【关键词】2型糖尿病；二甲双胍；效果；血脂指标

Objective To investigate the effects of metformin in the treatment of type 2 diabetes.Methods 50 cases of type 2 diabetic patients treated in the outpatient of our community health service center were randomly screened for study，and were given 3 month above treatment observation and follow-up.The fasting blood glucose，postprandial 2 h blood glucose，glycated hemoglobin before treatment，4 weeks after treatment，12 weeks after treatment and the adverse reactions during the treatment were observed and recorded，and were given statistical analysis.Results All the 50 cases were successively treated，and with the increase of treatment time，the fasting blood glucose，postprandial 2 h blood glucose，glycated hemoglobin were improved，in which 12 weeks was better than before the treatment（P＜0.05）.50 patients during treatment 1 to 2 weeks had 7 cases of adverse reactions，but the duration was short，then automatically ease.Conclusion The implementation of metformin in the type 2 diabetes can not only improve the blood sugar and lipid，but also has high safety.

【Key words】Type 2 diabetes mellitus，Metformin，Effect，Lipid levels

糖尿病属于常见疾病，以2型居多，约为90%以上［1］。根据美国糖尿病协会与《中国2型糖尿病防治指南》最新要求，糖尿病一经诊断，先实施控制饮食、运动锻炼等干预处理，若血糖未能达标，则首先可考虑采取二甲双胍治疗［2］。二甲双胍属于一线药物，尤其是肥胖型2型糖尿病有良好效果［3］。为进一步探讨二甲双胍应用在2型糖尿病中的效果，我社区中心针对门诊接诊的50例实施二甲双胍治疗的2型糖尿病进行回顾性分析，报道如下。