郭月平

[摘要] 目的 探讨榆柏散联合干扰素治疗高危型HPV感染慢性子宫颈炎的临床效果。 方法 选取本院2014年4月～2015年4月收治的121例高危型HPV感染慢性子宫颈炎患者作为研究对象，随机分为对照组（n=60）与观察组（n=61）。对照组给予单纯干扰素治疗，观察组给予榆柏散联合干扰素治疗，比较两组的治疗效果、治疗前后HPV病毒载量变化及HPV转阴率、不良反应发生率。 结果 观察组的总有效率为83.6%，显著高于对照组的68.3%，差异有统计学意义（P<0.05）。观察组治疗后的HPV病毒载量显著低于对照组，差异有统计学意义（P<0.05）。观察组的HPV转阴率为70.5%，显著高于对照组的51.7%，差异有统计学意义（P<0.05）。两组的不良反应发生率比较，差异无统计学意义（P>0.05）。 结论 榆柏散联合干扰素治疗高危型HPV感染慢性子宫颈炎效果显著，能够有效降低HPV病毒载量，提高HPV转阴率，无明显不良反应发生，值得临床推广应用。

[关键词] 榆柏散；干扰素；高危型HPV感染；慢性子宫颈炎；可行性；安全性

[中图分类号] R711.32 [文献标识码] A [文章编号] 1674-4721（2016）03（b）-0162-03

[Abstract] Objective To explore the clinical efficacy of Yubai powder combined with interferon in the treatment of high-risk HPV infection of chronic cervicitis. Methods 121 patients with high risk HPV infection of chronic cervicitis in our hospital from April 2014 to April 2015 were selected and randomly divided into the control group （n=60） and the observation group （n=61）.The control group was treated with interferon，the observation group was treated with Yubai powder combined with interferon.The treatment effect，change of HPV viral load before and after treatment，HPV negative rate，the incidence rate of adverse reaction was compared between the two groups. Results The total effective rate of the observation group was 83.6%，which was higher than 68.3% of the control group，with significant difference （P<0.05）.The HPV viral load after treatment in the observation group was lower than that in the control group，with significant difference （P<0.05）.The HPV negative rate of the observation group was 70.5%，which was higher than 51.7% of the control group，with significant difference （P<0.05）.There was no significant difference in the incidence rate of adverse reaction in the two groups （P>0.05）. Conclusion The effect of the traditional Chinese medicine Yubai powder combined with interferon in the treatment of high-risk HPV infection of chronic cervicitis is significant，which can effectively reduce HPV viral load，improve HPV negative rate，without obvious adverse reaction，it is worthy of clinical promotion and application.

[Key words] Yubai powder；Interferon；High-risk HPV infection；Chronic cervicitis；Feasibility；Safety慢性子宫颈炎（chronic cervicitis）是最常见的妇科疾病之一，临床表现为白带增多、痛经、下腹坠胀感，其致病病原体主要包括人乳头瘤病毒（HPV）、支原体、沙眼衣原体等，其中约60%的慢性子宫颈炎妇女合并HPV感染[1-2]。高危型HPV主要包括HPV16型与18型，除引起生殖器疣病外，还会导致宫颈癌前病变与癌变[3]，故早期对高危型HPV感染慢性子宫颈炎进行防治十分必要[4]。本研究采用榆柏散联合干扰素治疗高危型HPV感染慢性子宫颈炎，取得了较好的效果。

1 资料与方法

1.1 一般资料

选取本院2014年4月～2015年4月收治的121例高危型HPV感染慢性子宫颈炎患者作为研究对象，随机分为对照组（60例）与观察组（61例）。对照组中，平均年龄（32.16±8.15）岁，病程（53.17±23.15） d。观察组中，平均年龄为（31.84±8.03）岁，病程（54.79±24.16） d。……