周映彤 刘惠晶 邹达良

[摘要] 目的 分析利尿剂联合倍他司汀治疗梅尼埃病所致眩晕的临床价值及疗效。 方法 选择2012年10月～2015年9月112例接受我院治疗的因梅尼埃病所致的眩晕患者作为研究对象，依照治疗方案的不同将其分为研究组和对照组。对照组患者采用注射银杏叶制剂进行治疗；研究组患者采用利尿剂联合倍他司汀进行治疗。评价两组患者的临床疗效及预后，记录两组患者临床相关时间指标。 结果 研究组患者的治疗时间、临床症状消失时间较对照组均显著缩短，差异有统计学意义（P<0.05）；研究组患者治疗的总有效率显著高于对照组，差异有统计学意义（P<0.05）；两组头痛、出疹、心悸等并发症的发生率比较，差异无统计学意义（P>0.05）。 结论 利尿剂联合倍他司汀治疗梅尼埃病所致眩晕的临床效果显著，具有治疗时间短、并发症少、复发率低的特点，应予以推广应用。

[关键词] 梅尼埃病；利尿剂；倍他司汀；眩晕

[中图分类号] R255.3 [文献标识码] A [文章编号] 1674-4721（2016）03（b）-0150-03

[Abstract] Objective To analyze the clinical value and effect of diuretic combined with betahistine in the treatment of vertigo due to Meniere disease. Methods 112 patients suffering from vertigo due to Meniere disease who were treated in our hospital from October 2012 to September 2015 were selected as research samples.According to different therapeutic regimens，they were divided into research group and control group.In the control group，Ginkgo leaf preparation for injection was used.In the research group，diuretic combined with betahistine was applied.The clinical effect and prognosis were evaluated between the two groups and the clinical related time indexes were also recorded. Results In the research group，time of treatment and clinical symptoms disappearing was greatly shorter than that of the control group respectively，with statistical differences（P<0.05）.In the research group，the total clinical therapeutic effective rate was much higher than that in the control group，which was displayed a statistical difference（P<0.05）.The incidence of each symptom like headache，rash，and heart palpitation，etc. was almost the same.The difference in total occurrence rate of complications was not in statistical difference（P>0.05）. Conclusion Combination of diuretic and betahistine in the treatment of vertigo due to Meniere disease can obtain a remarkable effect in clinic at advantages of short therapeutic time，few complications，and low recurrence rate，which should be extensively applied.

[Key words] Meniere disease；Diuretics；Betahistine；Vertigo

梅尼埃病又称膜迷路积水，是一种特发性的内耳疾病，临床表现为耳闷和耳鸣、波动性听力下降及旋转性头晕[1]。临床上常采用传统的注射银杏叶制剂进行治疗，但其临床效果偏低，且病情易反复发作，不能特异性的针对病症予以根治[2-3]。为此我院新开展了利尿剂联合倍他司汀的疗法，并与传统银杏叶制剂疗法进行比较，分析其临床表现及应用效果，以期选出更为高效安全的治疗梅尼埃病所致眩晕的药物。

1 资料与方法

1.1 一般资料

根据用药种类及治疗方法的不同将2012年10月～2015年9月接受我院治疗的112例因梅尼埃病所致的眩晕患者随机平均分为研究组和对照组。……