周青美

[摘要] 目的 探讨奥曲肽联合奥美拉唑钠治疗肝硬化合并上消化道出血的临床效果。 方法 回顾分析我院2013年6月～2014年7月收治的肝硬化合并上消化道出血患者共56例，根据患者用药意愿将其分为观察组和对照组，各28例。两组患者均给予常规基础治疗，同时观察组给予奥曲肽联合奥美拉唑钠治疗；对照组给予胃肠减压、禁食、补液、营养支持等常规治疗。统计两组患者治疗效果，比较两组患者出血时间、住院时间、再出血率及不良反应发生率等临床指标。 结果 观察组治疗有效率（92.9%）明显高于对照组（78.6%），两组比较差异有统计学意义（P<0.05）。观察组患者在平均出血时间、平均住院时间及再出血率方面均优于对照组患者，两组比较差异有统计学意义（P<0.05）。观察组患者不良反应发生率（7.1%）低于对照组（25.0%），差异有统计学意义（P<0.05）。 结论 奥曲肽联合奥美拉唑钠治疗肝硬化合并上消化道患者有着良好的临床疗效，能帮助患者快速止血，缩短患者住院时间并降低患者再出血率，同时不良反应发生率低，值得临床推广。

[关键词] 奥曲肽；奥美拉唑钠；肝硬化合并上消化道出血；再出血

[中图分类号] R573.2 [文献标识码] A [文章编号] 1674-4721（2016）03（b）-0138-03

[Abstract] Objective To explore the clinical effect of octreotide combined with omeprazole sodium in treating hepatocirrhosis with upper gastrointestinal bleeding. Methods 56 hepatocirrhosis with upper gastrointestinal bleeding patients from July 2013 to July 2014 of our hospital were retrospectively analyzed.Patients were divided into observation group and control group according to their drug use will，and each group was 28 cases.All patients of two groups were given general routine treatment.Patients in observation group were given octreotide combined with omeprazole sodium，and patients in control group were given routine treatment liked gastrointestinal decompression，fasting， infusion and nutrition support.The treatment effects in two groups were counted.The clinical index included bleeding time，hospital stay，recurrent bleeding rate and the incidence rate of adverse effects between two groups were compared. Results The effective rate was 92.9% in observation group，obvious higher than that was 78.6% in control group，and the difference was statistical significance（P<0.05）.The averge bleeding time，averge hospital stay and recurrent bleeding rate in observation group was better than that of control group，and the difference was statistical significance（P<0.05）.The incidence rate of adverse effects was 7.1% in observation group，lower than that was 25.0% in control group，and the difference was statistical significance（P<0.05）. Conclusion Octreotide combined with omeprazole sodium in treating hepatocirrhosis with upper gastrointestinal bleeding has good clinical effects.It can help patients to stop bleeding quickly，short the hospital stay and recurrent bleeding rate of patients and have low incidence rate of adverse effects.It is worth to popularize.

[Key words] Octreotide；Omeprazole sodium；Hepatocirrhosis with upper gastrointestinal bleeding；Recurrent bleeding

肝硬化是我国临床门诊常见的慢性进行性肝脏疾病，是由一种或多种原因长期或重复作用于患者体内并引发患者弥漫性肝损害的疾病[1]。肝硬化患者早期临床症状并不明显，然而后期会引发患者肝功能损害、障碍、门脉高压等诸多症状，患者身体多个组织系统受到影响，出现上消化道出血、肝性脑病、脾功能亢进、腹水等多种并发症，其中上消化道出血是肝硬化患者晚期最常见的并发症之一[2]。本次研究旨在探讨奥曲肽联合奥美拉唑钠治疗肝硬化合并上消化道出血的临床效果。

1 资料与方法

1.1 一般资料

回顾我院2013年6月～2014年7月收治的肝硬化合并上消化道出血患者共56例，根据患者用药意愿将其分为观察组和对照组，各28例。……