谢怡

[摘要] 目的 探讨甲泼尼龙治疗青少年不同类型突发性耳聋的临床效果。 方法 收集我院2013年1月～2015年1月176例青少年不同类型突发性耳聋患者为研究对象，随机将其分为观察组和对照组，其中观察组88例患者采用甲泼尼龙进行治疗，对照组88例患者采用地塞米松进行治疗，对两组患者的突发性耳聋类型进行分类，比较听力曲线类型，观察两组患者的疗效结果并针对不同突发性耳聋类型的疗效进行比较，统计两组患者出现并发症的情况。 结果 观察组的痊愈率为77.3%，明显高于对照组的59.1%，两组差异有统计学意义（P<0.01）；两组患者中低中频类型的患者痊愈人数最多，为26例，其次为中高频21例，全频16例，最后为全聋类型10例。观察组的不良反应发生率为7.9%，明显低于对照组的20.4%，两组差异有统计学意义（P<0.05）；其中低中频类型的患者不良反应发生人数最少，为1例，其次为中高频7例，全频类型8例，全聋类型9例。 结论 甲泼尼龙在治疗青少年不同类型突发性耳聋上具有效果好、安全性高的特点，其中对低中频听力下降突发性耳聋患者的疗效最好，其次为中高频、全频率下降患者，而全聋型患者的效果最差。

[关键词] 突发性耳聋；甲泼尼龙；青少年；地塞米松

[中图分类号] R764.437 [文献标识码] A [文章编号] 1674-4721（2016）03（b）-0107-04

[Abstract] Objective To explore the clinical effects of methylprednisolone in treating adolescent different types of sudden deafness. Methods 176 adolescent different types of sudden deafness from January 2013 to January 2015 of our hospital were selected as study object.Patients were randomly divided into observation group and control group.88 patients in observation group were treated with methylprednisolone and 88 patients in control group were treated with dexamethasone.Types of sudden deafness in two groups were conducted with classification comparison.The results and effects of different types of sudden deafness in two groups were analyzed.The results of complications in two groups were compared. Results The cure rate in observation group was 77.3%，obvious higher than that was 59.1% in control group，and the difference was statistical significant （P<0.01）.The cure number in low-middle frequency type was the most （n=26），and then was the middle-high frequency type （n=21），the frequency type was 16 cases and the last was total deafness type （n=10）.The incidence rate of adverse effects in observation group was 7.9%，obvious lower than that was 20.4% in control group，and the difference was statistical significant （P<0.05）.The low frequency type patients had the lowest adverse effects （n=1），then was the middle-high frequency （n=7），the frequency type was 8 cases and the total deafness type was 9 cases. Conclusion Methylprednisolone in treating adolescent different types of sudden deafness has the feature with good effects and high safety.The low-middle frequency hearing loss sudden deafness has the best effects，and are following with middle-high frequency decline，the frequency decline patients，and the total deafness patients are worst.

[Key words] Sudden deafness；Methylprednisolone；Adolescent；Dexamethasone

突发性耳聋又称突聋[1]，是指突然发生且原因不明的感声神经性听力损失[2]。近年来，青少年突发性耳聋的发病率有上升的趋势，主要类型为低中频听力下降、全频率下降、中高频听力下降和全聋型[3]，临床上主要表现为单侧听力下降，并且可能会伴有耳鸣、眩晕、恶心、呕吐等不良反应[4]。近年来，糖皮质激素一直作为突发性耳聋的首选治疗方法，本研究通过对比甲泼尼龙和地塞米松对青少年不同类型突发性耳聋患者的治疗效果及其并发症的发生情况，探讨甲泼尼龙治疗青少年不同类型突发性耳聋的临床价值。

1 资料与方法

1.1一般资料

收集我院2013年1月～2015年1月176例青少年不同类型突发性耳聋患者为研究对象，随机将其分为观察组和对照组，观察组88例患者中，男性患者48例，女性患者40例；……