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TORCH系列病原微生物感染与早产的相关性研究

2016-07-11凌卫滨谢淑霞潘关凤车伟坤

中国当代医药 2016年8期
关键词:检测

凌卫滨 谢淑霞 潘关凤 车伟坤

[摘要] 目的 探讨TORCH系列病原微生物感染与早产的相关性。 方法 选择2013年1月~2015年10月于我院分娩的产妇,根据是否为足月分娩分为研究组与对照组,其中研究组均为足月分娩产妇,对照组均为早产产妇,每组120例。所有产妇分娩后均采集外周血2 ml,并接受TORCH系列抗体IgG及IgM检测,比较两组产妇弓形虫(TOX)、风疹病毒(RUV)、巨细胞病毒(CMV)、单纯疱疹病毒(HSV)IgG及IgM的阳性检测率。 结果 ①IgG阳性检测率:研究组RUV、CMV、TOX、HSV IgG阳性检测率分别为40.00%、34.17%、10.00%、16.67%,对照组分别为13.33%、9.17%、0、1.67%,两组比较差异有统计学意义(P<0.05)。②IgM阳性检测率:研究组RUV、CMV、TOX、HSV IgM阳性检测率分别为23.33%、25.00%、10.83%、11.67%,对照组分别为4.17%、5.00%、0、0,两组比较差异有统计学意义(P<0.05)。③IgG与IgM双项阳性检测率:研究组RUV、CMV、TOX、HSV双项阳性检测率分别为20.83%、22.50%、3.33%、3.33%,对照组分别为1.67%、3.33%、0、0,两组比较差异有统计学意义(P<0.05)。 结论 早产与孕妇TORCH系列病原微生物感染的关系密切,孕期行TORCH筛查是预防和减少临床早产的重要手段。

[关键词] TORCH系列病原微生物;早产;相关性

[中图分类号] R722.6 [文献标识码] A [文章编号] 1674-4721(2016)03(b)-0095-03

[Abstract] Objective To study the correlation of the infection of TORCH pathogenic organism with premature delivery. Methods The puerperant who delivered in our hospital from January 2013 to October 2015 were selected.The subjects were divided into study group and control group according to the condition of full term birth,120 cases in each group.The study group were full term puerperant and the control group were premature maternal.2 ml of peripheral blood was collected in receiving the detection of TORCH antibody IgG and IgM.The positive detection rate of TOX,RUV,CMV and HSV IgG and IgM between two groups was compared. Results ①IgG:the positive detection rate of RUV,CMV,TOX and HSV IgG in study group was 40.00%,34.17%,10.00%,16.67%;the rate of control group was 13.33%,9.17%,0,1.67%,with statistical difference(P<0.05).②IgM:the positive detection rate of RUV,CMV,TOX and HSV IgM in study group was 23.33%,25.00%,10.83%, 11.67%;the rate of control group was 4.17%,5.00%,0,0,with statistical difference(P<0.05).③IgG and IgM:the positive detection rate of RUV,CMV,TOX and HSV IgG and IgM for study group was 20.83%,22.50%,3.33%,3.33%;the rate of control group was 1.67%,3.33%,0,0,with statistical difference(P<0.05). Conclusion The premature delivery has a close correlation with the infection of TORCH pathogenic organism.During the gestation period,the TORCH screening is an effective way to prevent and reduce the incidence rate of premature delivery.

[Key words] TORCH pathogenic organism;Premature delivery;Correlation

TORCH是一组病原微生物的英文缩写名称[1],其中弓形虫(TOX)简写为T;梅毒螺旋体等其他病原体简写为O;风疹病毒(RUV)简写为R;巨细胞病毒(CMV)简写为C;单纯疱疹病毒(HSV)简写为H。目前研究表明,当孕妇感染上述任一病原体后,往往不会表现出明显的临床症状[2],但上述致病病原体可通过胎盘使胎儿感染,引发流产、死胎或胎儿先天缺陷等情况[3]。此外,致病病原体还能通过产道或母乳引发新生儿感染[4]。为进一步探讨TORCH系列病原微生物感染与早产的相关性,笔者对240例于我院分娩的产妇进行了临床分组观察,现报道如下。

1 资料与方法

1.1 一般资料

本研究共纳入产妇240例,均为2013年1月~2015年10月于我院分娩的产妇。根据是否为足月分娩分为研究组与对照组,其中研究组均为足月分娩产妇,对照组均为早产产妇,每组120例。研究组:年龄20~36岁,平均(27.2±6.3)岁,孕次1~3次,平均(1.4±0.8)次;……

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