左万江

摘 要 目的：探讨妥洛特罗透皮贴剂对支气管哮喘持续期患儿的辅助治疗作用。方法：选取我院儿科支气管哮喘持续期患儿115例，其中对照组57例，采用常规治疗，观察组58例，在对照组基础上采用妥洛特罗透皮贴剂经皮治疗，比较两组患儿临床疗效的差异。结果：观察组治愈率明显高于对照组，观察组咳痰、咳嗽、哮鸣音和喘憋消失时间均明显短于对照组（P<0.05）。治疗前，两组肺功能指标（FVC、FEV1、PEF、MMEF、V50）与免疫指标（EOS、TIgE）水平比较差异无统计学意义（P>0.05），治疗后，全部患儿肺功能指标水平均明显高于治疗前，免疫指标水平均明显低于治疗前（P<0.05）。观察组肺功能指标水平明显高于对照组，免疫指标水平明显低于对照组（P<0.05）。两组患儿药物总不良反应率比较差异无统计学意义（P>0.05）。结论：妥洛特罗透皮贴剂对支气管哮喘持续期患儿具有重要的辅助治疗作用，有助于显著改善临床症状、肺功能与免疫功能，且药物安全性较高，值得临床推广应用。

关键词 妥洛特罗透皮贴剂 支气管哮喘 抗过敏治疗

中图分类号：R974.3； R725.6 文献标识码：A 文章编号：1006-1533（2016）07-0025-04

Adjuvant effect of Tulobuterol patch in the treatment of 58 cases of children with bronchial asthma at persistent period*

ZUO Wanjiang

（Department of Pediatrics， The Traditional Chinese Medicine Hospital of Jinxi County， Fuzhou 344800， China）

ABSTRACT Objective： To investigate an adjuvant effect of Tulobuterol transdermal patch on children with bronchial asthma. Methods： One hundred fifteen cases of children with bronchial asthma at persistent period were selected from department of pediatrics of our hospital and divided into a control group （n=57） and an observation group （n=58）. The control group was treated with conventional therapy while the observation group with transdermal therapy of Tulobuterol patch on the based of control group. Clinical curative effects were compared between the two groups. Results： The cure rate of the observation group was significantly higher than that of the control group， and the disappeared times for sputum， cough， wheezing rales and wheezing were significantly shorter in the observation group than the control group （P< 0.05）. Before treatment， the comparison of lung function indexes （FVC， FEV1， MMEF， V50， PEF） and immune indexes （TIgE， EOS） between the two groups showed no statistical significance （P>0.05）. All the indexes were significantly higher for lung function and were significantly lower for immune function after treatment than before （P<0.05） and all the indexes for both lung function and immune were much better in the observation group than the control group （P<0.05）. There were no significant differences in the total adverse drug reactions between the two groups （P>0.05）. Conclusion： Tulobuterol transdermal patch has an important adjuvant effect in the treatment of children with bronchial asthma at persistent period， is of benefit to prominently improving clinical symptoms and lung and immune function with higher drug safety， and is worthy of clinical popularization and application.

KEY WORDS Tulobuterol transdermal patch； bronchial asthma； antiallergy therapy

支气管哮喘发作时，患儿出现咳嗽、喘息等临床症状，随着病情的逐渐加重，甚至导致支气管哮喘患儿死亡。相关文献显示，化痰、雾化吸入、抗过敏、抗感染与改善肺微循环治疗是支气管哮喘患儿的常规治疗手段，但常规治疗对支气管哮喘患儿的临床疗效的改善作用具有一定的局限性[1]。本研究探讨妥洛特罗透皮贴剂对支气管哮喘持续期患儿的辅助治疗作用，以指导临床治疗，现报道如下。

1 资料与方法

1.1 临床资料

选取2015年1月—2015年11月期间金溪县中医院儿科支气管哮喘持续期患儿115例，采用随机数字表法将其分为观察组与对照组。观察组：58例，其中男30例，女28例，年龄5～13岁，平均年龄（8.51±2.01）岁，病程1～25个月，平均病程（11.98±0.64）个月；……