曾晓红，吴涤心，傅存冀(乌鲁木齐市第一人民医院药剂科，乌鲁木齐　830002)



药学干预对2型糖尿病患者用药依从性及药品不良反应的影响

曾晓红*，吴涤心，傅存冀(乌鲁木齐市第一人民医院药剂科，乌鲁木齐830002)

DOI10.14009/j.issn.1672-2124.2016.01.044

摘要目的：观察药学干预对2型糖尿病患者用药依从性及药品不良反应(adverse drug reaction，ADR)的影响。方法：采用随机双盲法，将我院2013年1月—2014年12月收治的100例2型糖尿病患者分为对照组与观察组，2组各50例。对照组患者采取常规用药干预，观察组患者则进行药学干预，比较2组患者用药依从性、ADR发生率及干预前、后空腹血糖及餐后2 h血糖变化。结果：观察组患者的用药总依从率为98.0%，对照组患者的用药总依从率为78.0%，2组的差异有统计学意义(P﹤0.01)。观察组患者的ADR发生率、用药偏差发生率分别为20.0%、16.0%，均显著低于对照组的44.0%、40.0%，差异有统计学意义(P﹤0.05)。观察组患者出院时空腹血糖、餐后2 h血糖明显低于对照组，差异有统计学意义(P﹤0.01)。结论：药学干预能明显提高2型糖尿病患者的用药依从性，降低ADR发生率，进而能更好地控制血糖。

关键词药学干预； 2型糖尿病； 用药依从性； 药品不良反应

Effects of Pharmaceutical Intervention on Medication Compliance and Adverse Drug Reactions in Patients with Type 2 Diabetes Mellitus

ZENG Xiaohong, WU Dixin, FU Cunji(Dept.of Pharmacy, the First People’s Hospital of Urumqi, Urumqi 830002, China)

ABSTRACTOBJECTIVE：To observe the effects of pharmaceutical intervention on medication compliance and adverse drug reactions (ADR) in patients with type 2 diabetes mellitus. METHODS: Random double blind method was adopted, 100 cases with type 2 diabetes admitted into our hospital from Jan.2013 to Dec. 2014 were randomly divided into control group and observation group, with 50 cases in each. The control group were treated with routine medication intervention while the observation group received pharmaceutical intervention; medication compliance and incidence of ADR, and changes of fasting blood glucose and postprandial 2 h blood glucose before and after intervention were compared between two group of patients. RESULTS: The total medication compliance rate of the observation group was 98.0% while of the control group was 78.0%, with statistically significant difference(P﹤0.01). The incidence of ADR and drug use deviation in the observation group were respectively 20.0% and 16.0%, significantly lower than those in the control group 44.0% and 40.0%, with statistically significant difference(P﹤0.05). The fasting blood glucose and postprandial 2 h blood glucose in the observation group were significantly lower than those in the control group when discharged (P﹤0.01). CONCLUSIONS: Pharmaceutical intervention can significantly improve the medication compliance of patients with type 2 diabetes, reduce the incidence of ADR, and can better control the blood glucose.

KEYWORDSPharmaceutical intervention; Type 2 diabetes mellitus; Medication compliance; ADR

2型糖尿病易引发相关并发症，为此临床常采取多药联合治疗，且用药时间一般较长[1-2]。相关研究及临床实践均表明，患者的用药依从性在很大程度上直接关系到血糖的控制效果，而用药依从性与患者对疾病相关知识的认知度、药品不良反应(adverse drug reaction，ADR)等密切相关[3]。笔者于2013年1月—2014年12月对乌鲁木齐市第一人民医院(以下简称“我院”)收治的2型糖尿病患者进行药学干预，探讨其对患者用药依从性及ADR的影响，现报告如下。……