王红梅



甲钴胺口服与维生素B12肌注治疗巨幼红细胞性贫血的临床疗效比较

王红梅

【摘要】目的 对比分析甲钴胺和维生素B12治疗巨幼红细胞性贫血的效果。方法 选取我院治疗收治的150例巨幼红细胞性贫血患者为研究病例，随机分为研究组75例（口服甲钴胺治疗）和对照组75例（肌注维生素B12治疗），跟踪随访，观察比较两组的疗效。结果 治疗后两组血红蛋白含量、血小板高于治疗前，红细胞平均体积低于治疗前，差异有统计学意义（P＜0.05）；在相同时间点，两组血常规各项指标差异无统计学意义（P＞0.05）。结论 口服甲钴胺治疗巨幼红细胞性贫血的效果与肌注维生素B12的效果均较好。

【关键词】甲钴胺；维生素B12；巨幼红细胞性贫血

Objective To compare the effect of mecobalamin oral and intramuscular injection of vitamin B12in the treatment of megaloblastic anemia. Methods 150 cases with megaloblastic anemia were selected as the research cases in our hospital. They were randomly divided into study group（mecobalamin oral treatment，n=75）and control group （intramuscular injection of vitamin B12treatment，n=75），a follow-up was made and the curative effect was observed and compared between the two groups. Results After treatment，the hemoglobin and platelets were significantly higher than that before treatment in two groups，the mean corpuscular volume was significantly lower than that before treatment（P＜0.05），the difference was significant. At the same time，there were no significant differences in blood routine indicators in two groups（P＞0.05）. Conclusion The effect of mecobalamin oral treatment is better than intramuscular injection of vitamin B12for the treatment of megaloblastic anemia.

【Key words】 Mecobalamin，Vitamin B12，Megaloblastic anemia

巨幼细胞性贫血作为临床较为常见的营养性贫血疾病，其发病原因主要与体内叶酸或维生素B12缺乏导致造血细胞DNA合成障碍而出现无效性红细胞［1-3］。本实验通过对比不同药物治疗巨幼细胞性贫血的效果，旨在为巨幼细胞性贫血的治疗提供新思路，现将结果总结如下。

1　一般资料

1.1研究对象

选取我院血液科在2013年10月～2015年12月确诊为巨幼细胞性贫血的150例患者为分析对象，分为研究组和对照组各75例，研究组中男性53例，女性22例，患者年龄34～62岁，平均年龄（54.98±3.54）岁；对照组中男性52例，女性23例，患者年龄33～64岁，平均年龄（54.82±3.47）岁。本实验病例纳入标准：（1）经骨髓象检测确诊为巨幼红细胞性贫血［4］；（2）血清维生素B12＜200 pg/ml，且血清叶酸＞3 ng/ml；（3）首次发病，既往无贫血、白血病等血液疾病；（4）近30 d内未接受补充维生素的相关治疗；……