南海峰



熊去氧胆酸治疗原发性胆汁性肝硬化的临床观察

南海峰

【摘要】目的 探讨采用熊去氧胆酸对原发性胆汁性肝硬化进行治疗的临床效果。方法 选择本院住院及门诊诊治的原发性胆汁性肝硬化患者86例，将其随机分为观察组和对照组，各43例。两组患者均给予保肝及支持治疗，对照组予以口服泼尼松龙，观察组给予以口服熊去氧胆酸。两组患者均治疗4周为1个疗程。结果 两组临床治疗总有效率明显高于对照组，差异有统计学意义（P＜0.05）。结论 熊去氧胆酸治疗原发性胆汁性肝硬化临床疗效显著，能更好改善患者临床症状，及肝功能异常指标，并具有良好的安全性。

【关键词】熊去氧胆酸；胆汁性；肝硬化；疗效

Objective To discuss the clinical effect of primary biliary cirrhosis treated by ursodesoxycholic acid. Methods To selected 86 cases patients with primary biliary cirrhosis in outpatient clinic at our hospital，to randomly divided into the treatment group and the control group，each group had 43 cases. The patients were given the liver protection and supportive treatment，the control group was given the prednisolone by oral，and the treatment group was given the ursodesoxycholic acid by oral. They were treated for 4 weeks as one course of treatment. Results The total effective rate of clinical treatment of the treatment group was significantly greater than the control group，there was statistical significance（P＜0.05）. Conclusion That has the significantly clinical effect of primary biliary cirrhosis treated by ursodesoxycholic acid，and preferable improve the clinical symptoms and anomaly index of liver function，that has the favourable security.

【Key words】 Ursodesoxycholic acid，Biliary，Liver cirrhosis，Treatment effect

肝内胆汁淤积是临床多发疾病，随着生活水平的提高，人们的饮食结构和饮食习惯正趋于多样化，增加了原发性胆汁性肝硬化发病率［1］。原发性胆汁性肝硬化常与免疫系统疾病一起发作，例如风湿性关节类、慢性淋巴细胞性甲状腺炎、干燥综合征等，本病多发于中年女性，患者开始没有任何临床表现，起病隐袭，病程缓慢。因此，临床应提高黄疸的鉴别力度，以避免出现继发性胆汁性肝硬变及其他原因肝硬化。本病与自身免疫力有相关关系，但主要原因尚不明确。从目前治疗原发性胆汁性肝硬化的临床研究来看，有一些学者认为熊去氧胆酸治疗原发性胆汁性肝硬化具有比较好的疗效。笔者进行了相关研究，报道如下。

1　资料与方法

1.1一般资料