乌鸡白凤丸抗炎、镇痛及抗应激的药效学研究

陈家艺，吴清和，黄萍，操红缨*

(广州中医药大学，广州511400)

摘要：目的探讨乌鸡白凤丸抗炎、镇痛及抗应激作用，为其临床应用提供科学的理论依据。方法采用二甲苯致小鼠耳廓肿胀实验、蛋清致大鼠足趾肿胀实验以及大鼠棉球肉芽肿实验，观察乌鸡白凤丸的抗炎作用；应用小鼠热板法、醋酸扭体法观察该药的镇痛作用；通过小鼠耐疲劳、耐缺氧、耐寒冷实验观察该药的抗应激作用。结果抗炎方面：乌鸡白凤丸可显著抑制二甲苯所致小鼠耳廓肿胀度及大鼠致炎后足肿胀度，降低大鼠肉芽肿系数；镇痛方面：乌鸡白凤丸可提高热板法引起的小鼠痛阈值，抑制醋酸所致小鼠扭体反应；抗应激方面：乌鸡白凤丸能增加小鼠负荷游泳时间，延长小鼠常压耐缺氧的存活时间，降低小鼠在低温环境中的死亡率。结论乌鸡白凤丸具有显著的抗炎、镇痛及抗应激作用。

关键词:乌鸡白凤丸；抗炎作用；镇痛作用；抗应激作用

doi:10.3969/j.issn.1004-2407.2015.03.012

中图分类号：R965

文献标志码：A

文章编号：1004-2407(2015)03-0256-05

Abstract:ObjectiveTo investigate the anti-inflammatory, analgesic and anti-stress effects of Wujibaifeng Pills.Methods The anti-inflammatory action of Wujibaifeng Pills was assessed by ear edema induced by using xylene in mice and injected egg white in rats； the analgesic effect was tested by using the rat body torsion test and hot-plate test；antifatigue, anti-anoxia and low temperature-resistant tests were used for evaluating the effects on anti-stress. ResultAnti-inflammatory aspects: Wujibaifeng Pills high-dose can significantly inhibit mouse auricle swelling caused by dimethylbenzene and rats foots swelling， in addition can also decrease the granuloma of rats. Analgesic aspects: Wujibaifeng Pills can increase the pain threshold，inhibit body torsion reaction caused by acetic acid.Stress resistance aspect:Wujibaifeng Pills can obviously increase the weight loaded swimming time in mice，and can prolong the survival time of bearing hypoxia at normal pressure in mice and significantly reduce the mortality rate of mice in the low temperature environment in mice. Conclusion Wujibaifeng Pills have significant anti-inflammatory, analgesic action and can improve the ability of the body′s resistance to stress.

基金项目：中央财政支持地方高校发展专项资金项目(编号：财教[2013]338号)

作者简介：陈家艺，女，在读硕士研究生

收稿日期：(2014-12-22)

Study on the anti-inflammatory, analgesic and anti-stress effect of Wujibaifeng Pills

CHEN Jiayi，WU Qinghe，HUANG Ping，CAO Hongying*(Guangzhou University of Chinese Medicine，Guangzhou 511400，China)

Key words: Wujibaifeng Pills；anti-inflammatory；analgesia；anti-stress

*通信作者：操红缨，女，副教授，博士

乌鸡白凤丸系明代龚廷贤《寿世保元》中乌鸡丸的加减方，由乌骨鸡、人参、黄芪、丹参、当归、白芍、川芎等20味中药组成，集温补、涩敛、滋阴、调和等法为一方，具有补而不滞、温而不燥的特点[1]。近年来，乌鸡白凤丸药理作用研究主要集中在补血、止血、调脂、保肝、治疗慢性前列腺炎及骨质疏松症等方面[2]，但关于乌鸡白凤丸作为妇科良药临床常用于调经止带、抗炎镇痛的药理作用却少见较为全面的药效学研究，缺乏科学的理论依据。……