张俊英

[摘要] 目的 观察长春西汀联合疏血通治疗急性脑梗死的临床效果。 方法 选取为2013年1月～2015年1月之间我院收治的90例急性脑梗死患者，入院后均经影像学检查确诊，排除脑出血、急性心肌梗死、心绞痛及其他出血倾向疾病。90例确诊的急性脑梗死患者采用数字表法随机分为观察组和对照组，每组各45例，两组均予抗凝、减轻脑水肿、抗炎及预防并发症、纠正水电解质紊乱等常规对症治疗，观察组同时加用长春西汀20 mg加入0.9%氯化钠注射液250 mL静滴，每天1次，疏血通6 mL加入5%葡萄糖注射液250 mL静滴，每天1次，疗程14 d。比较两组治疗14 d后的总有效率以及两组患者治疗前后NIHSS评分的变化。 结果 观察组治疗后的总有效率为97.8%，显著高于对照组的77.8%，差异具有统计学意义（P<0.05）。观察组患者治疗后NIHSS评分显著低于对照组（P<0.05）。结论 长春西汀联合疏血通治疗急性脑梗死疗效确切，能够有效改善患者的神经功能， 值得在临床上推广和应用。

[关键词] 急性脑梗死；长春西汀；疏血通；NIHSS评分

[中图分类号] R743.3 [文献标识码] B [文章编号] 1673-9701（2015）34-0034-03

Observation of the clinical effect of vinpocetine combined with Shuxuetong injection in treatment of acute cerebral infarction

ZHANG Junying

Department of Neurology， Yantai Zhifu Hospital in Shandong Province， Yantai 264000， China

[Abstract] Objective To observe the clinical effect of vinpocetine combined with Shuxuetong injection in treatment of acute cerebral infarction. Methods A total of 90 patients with acute cerebral infarction in our hospital from Jan 2013 to Jan 2015 were selected， which were confirmed by imaging examination， excluding cerebral hemorrhage， acute myocardial infarction， angina and other bleeding tendency. 90 patients were randomly divided into observation group and control group， each of 45 cases， two groups were treated with anticoagulation， alleviate cerebral edema for acute cerebral infarction patients， anti-inflammatory and prevention of complications， correct water and electrolyte disorders and other conventional symptomatic treatment， observation group treated with vinpocetine 20 mg adding 0.9% sodium chloride injection 250 mL intravenous drip， 1 time a day， 6 mL of Shuxuetong added 5% glucose injection 250 mL intravenous drip， 1 time a day， with a course of 14 days. The total effective rate of two groups after treatment for 14 d and the change of NIHSS score before and after treatment in two groups were compared. Results The total effective rate of the observation group was 97.8%， significantly higher than 77.8% of control group， the difference was statistically significant （P<0.05）. After treatment， the NIHSS score of the observation group was significantly lower than that of the control group （P<0.05）. Conclusion Vinpocetine combined with Shuxuetong in treatment of acute cerebral infarction curative effect exact， can effectively improve the patient's neurological function， is worth the clinical promotion and application.

[Key words] Acute cerebral infarction； Vinpocetine； Shuxuetong； NIHSS score

急性脑梗死（acute cerebral infarction，ACI）系属于神经内科的常见病、多发病，治疗多以降低血液粘度，改善脑血液循环，减轻继发性神经细胞损伤为原则[1]。长春西汀属吲哚类生物碱，具有防治脑缺血、脑动脉粥样硬化、中风后遗症以及高血压、冠心病等的作用[2]。疏血通是由中药水蛭和地龙组合而成的复方注射液，是一种特异性凝血酶抑制剂，具有抗凝、促进纤溶、改善血液流变学、调节血脂及保护血-脑脊液屏障，减轻脑水肿，促进神经功能恢复的作用[3]。本研究旨在观察二者联用治疗急性脑梗死的临床效果，现报道如下。

1 资料与方法

1.1 一般资料

选取为2013年1月～2015年1月之间我院收治的90例急性脑梗死患者，入院后均经影像学检查确诊，排除脑出血、急性心肌梗死、心绞痛及其他出血倾向疾病。……