益气养阴中药治疗2型糖尿病血管病变

沈学然

(张家口市第二医院 内一科，河北 张家口 075000)

摘要：目的观察益气养阴中药对2型糖尿病血管病变(DA)的治疗作用及其对患者血清超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)水平的影响。方法选取2013年10月—2014年5月间我院收治的2型DA患者148例，随机分为治疗组与对照组，2组患者入院均给予糖尿病常规治疗，治疗组在常规治疗的基础加用益气养阴中药参芪复方治疗，参芪复方由人参、黄芪、山药、生地黄、天花粉、山茱萸、制大黄、丹参组成，水煎服，3次/d，150 mL/次;对照组只进行糖尿病常规治疗；2组患者均治疗8周,对比2组患者治疗前血清hs-CRP、IL-6水平、中医症候积分改善及临床疗效。结果2组患者治疗后血清hs-CRP、IL-6分别为(2.41±1.16) mg/L、(4.69±1.56) mg/L,(7.44±3.12) ng/L、(10.60±5.6) ng/L，较治疗前显著下降(P<0.05);治疗组治疗后血清hs-CRP、IL-6比较显著低于对照组(P<0.05)；2组治疗4周后中医症候积分较治疗前显著下降(P<0.05)，治疗8周后2组中医症候积分较治疗4周及治疗前下降更为显著(P<0.05)；治疗组患者治疗4、8周时中医症候积分(16.42±4.44、9.39±3.11)均显著低于对照组(18.29±2.77、12.31±4.38)(P<0.05);治疗组患者治疗后治疗组总有效率显著高于对照组(P<0.05)。结论益气养阴中药参芪复方可有效改善DA患者临床症状，降低hs-CRP、IL-6水平，改善患者血管炎症状态。

关键词：益气养阴；中药；DA；hs-CRP；IL-6

DOI:10.13463/j.cnki.jlzyy.2015.02.014

中图分类号：R587.1文献标志码： A

文章编号：1003-5699(2015)02-0147-03

基金项目:张家口市科学技术研究与发展指导计划项目(1221022D)。

作者简介:沈学然(1976-)，女，大学本科，副主任医师，主要从事糖尿病与心血管方面研究。

收稿日期:(责任编辑：王丹2014-08-18)

Yiqi Yangyin of traditional Chinese medicine treating for type 2 diabetic angiopathy

SHEN Xueran

(Internal Medical Department of the Second Hospital of Zhangjiakou City,Zhangjiakou 075000,Hebei Province,China)

Abstract:ObjectiveTo observe the therapeutic effect of Yiqi Yangyin traditional Chinese medicine on type 2 diabetic angiopathy (DA) and the effect on the patients’ serum high-sensitivity C-reactive protein (hs-CRP) and interleukin-6 (IL-6) levels.MethodsA total of 148 patients with type 2 DA who were admitted in our hospital from October,2013,to May,2014 were enrolled in the study and randomized into the treatment group and the control group.The patients in the two groups were given conventional diabetes treatment on admission.On the basis of conventional treatment,the treatment group received additional Yiqi Yangyin traditional Chinese medicine,the Shenqi compound recipe consisting of ginseng,astragalus,yam,radix rehmanniae,radix trichosanthis,dogwood,prepared rhubarb,and salvia miltiorrhiza,which was decocted three times every day,150 mL every time.The control group only received conventional treatment of diabetes.The patients in the two groups were treated for 8 weeks.The serum hs-CRP and IL-6 levels,the TCM symptom scores and the clinical efficacy in the patients of the two groups before and after treatment were compared.ResultsThe serum hs-CRP and IL-6 levels in the two groups after treatment were 2.41±1.16 mg/L,4.69±1.56 mg/L,7.44±3.12 ng/L,10.60±5.6 ng/L,significantly reduced when compared with those before treatment (P<0.05),and the serum hs-CRP and IL-6 levels in the treatment group (16.42±4.44,9.39±3.11)after treatment were significantly lower than those in the control group (18.29±2.77,12.31±4.38) (P<0.05).The TCM symptom scores in the two groups after 4-week treatment were significantly decreased when compared with those before treatment (P<0.05),the TCM symptom scores in the two groups after 8-week treatment were more obviously lower than those 4-week after treatment and before treatment (P<0.05).The TCM symptom scores in the treatment group after 4-week and 8-week treatment were significantly lower than those in the control group (P<0.05).The total effective rate in the treatment group after treatment was significantly higher than that in the control group (P<0.05).ConclusionThe Yiqi Yangyin traditional Chinese medicine,the Shenqi compound recipe,can effectively improve the DA patients’ clinical symptoms,reduce the hs-CRP and IL-6 levels,ameliorate the patients’ vascular inflammation status.

Keywords:Yiqi Yangyin;traditional Chinese medicine;DA;hs-CRP;IL-6

糖尿病(DM)为临床常见病，是由胰岛素分泌障碍引起的以患者血糖异常增高为主要临床表现的代谢性疾病，且随着生活水平的提高，发病呈逐年增高趋势[1-3]。据统计[4]，我国每年新增DM患者近100万。糖尿病血管病变(DA)是糖尿病患者常见并发症,是DM患者致伤、致残的重要原因[5-6]。笔者为观察益气养阴中药对2型糖尿病血管病变(DA)治疗作用及其对患者血清超敏C反应蛋白(hs-CRP)、白介素-6(IL-6)水平的影响，选取我院收治的2型DA患者，给予益气养阴中药参芪复方治疗，取得良好效果,现报道如下。……