低剂量沙利度胺结合常规化疗治疗多发性骨髓瘤的临床价值研究

何国民，徐娟，蔡亚云，贲海祥，陈婷

如皋市人民医院血液科，江苏如皋226500

[摘要]目的研究和讨论应用低剂量沙利度胺结合常规化疗对多发性骨髓瘤患者进行治疗的临床疗效情况。方法随机抽选2007年1月—2014年12月以来，在该院血液科进行治疗的100例多发性骨髓瘤患者。按照入院就诊时间将他们划分成对照组和观察组两组（每组各50例），分别采用常规化疗以及低剂量沙利度胺结合常规化疗进行临床诊治，并观察、分析和统计两组患者的治疗情况和临床效果。结果统计学比较显示，两组患者经过治疗后，其血M蛋白、血红蛋白浓度以及骨髓浆细胞值较之治疗前均有明显好转，且观察组明显优于对照组；观察组患者的临床总有效率（82.0%）以及OS、PFS值均明显高于对照组患者（52.0%），组内及组间对比结果的差异具有统计学意义（P＜0.05）。结论采用低剂量沙利度胺结合常规化疗对多发性骨髓瘤患者进行诊治，其临床疗效显著，能够有效改善患者指标情况，提高临床治疗效果，延迟患者生存时间，因此，它是一种有效、安全、理想、科学的临床诊治方法。

[关键词]多发性骨髓瘤；化疗；低剂量沙利度胺；临床效果

[中图分类号]R733.3

[文献标识码]A

[文章编号]1674-0742（2015）10（a）－0133-03

[作者简介]何国民(1969－)，男，江苏如皋人，学士，副主任医师，研究方向：恶性血液病诊治。

Abstract[]Objective To study and discuss the use of low-dose thalidomide in combination with conventional chemotherapy clini鄄cal efficacy in patients with multiple myeloma treatment.Methods A randomized lottery since January 2007 - December 2014, in hematology hospital for treatment of 100 cases of multiple myeloma patients.Visited the hospital in accordance with the time they divided into two groups control group and observation group (n=50 patients), respectively conventional chemotherapy and low-dose thalidomide in combination with conventional chemotherapy for clinical diagnosis and treatment, and to observe, analyze and sta鄄tistical groups of patients The treatment and clinical results.Results The statistical comparison shows that the two groups of pa鄄tients after treatment, the blood M protein, hemoglobin concentration, and the value of bone marrow plasma cells were significantly improved compared with before treatment, and the observation group than the control group; total clinical observation group of pa鄄tients The response rate (82.0%) and OS, PFS were significantly higher in patients (52.0%), comparison between the results of the group and the group differences obviously, were statistically significant (P<0.05).Conclusion The low dose of thalidomide in com鄄bination with conventional chemotherapy for treatment of multiple myeloma patients, the clinical effect is significant, can improve the index patient, improve clinical treatment, survival time delay, therefore, it is an effective , security, ideals, scientific clinical diagnosis and treatment.

收稿日期：（2015-06-26）

The Clinical Value of Low Dose Thalidomide Combined With Conventional Chemotherapy in the Treatment of Multiple Myeloma

HE Guo-min, XU Juan, CAI Ya-yun, BEN Hai-xiang, CHEN Ting

Department of Hematology, Rugao People's Hospital, Rugao, Jiangsu Province, 226500 China

[Key words]Multiple myeloma; Chemotherapy; Low-dose thalidomide; Clinical effect

多发性骨髓瘤，简称MM（Multiple myeloma），是血液科临床上的一种恶性浆细胞肿瘤疾病[1]。它的临床治愈率较低，且复发率、死亡率较高，其临床症状主要表现为骨痛、病理骨折、骨骼变形、出血、贫血、神经系统异常、肾功能损害等，对患者的生命安全危害严重[2-3]。……