靶向药物对肺癌脑转移的治疗效果

戴继鑫1，纪炜2

1.吉林省肿瘤医院内一科，吉林长春130000;2.吉林省前卫医院内分泌科，吉林长春130000

[摘要]目的对靶向药物治疗肺癌脑转移的效果进行分析探讨。方法整群选取该院2014年1月—2015年1月收治的66例肺癌脑转移患者，随机分为对照组和观察组，对照组33例患者行培美曲塞联合卡莫司汀治疗，观察组33例患者以吉非替尼治疗，对比两组患者的治疗效果及不良反应发生率。结果观察组的治疗有效率为57.58%，对照组的治疗有效率为24.24%，观察组的治疗有效率明显高于对照组，P<0.05，差异具有统计学意义。两组患者的不良反应的发生率比较，差异无统计学意义（P>0.05）。结论对肺癌脑转移患者采用吉非替尼治疗可有效提高治疗效果，降低不良反应的发生率，值得临床推广借鉴。[关键词]培美曲塞；吉非替尼；肺癌脑转移

[中图分类号]R734

[文献标识码]A

[文章编号]1674-0742（2015）10（a）－0128-02

[作者简介]戴继鑫（1978.12-），男，吉林辉南人，硕士研究生，主治医生，研究方向：内科学。

The Effect of Targeted Drugs for the Treatment of Brain Metastases from Lung Cancer

DAI Ji-xin1, JI Wei2

1.Department of Inside 1 Section, Tumor Hospital of Jilin Province, Changchun, Jilin Province, 130000 China;2.Department of Endocrinology, Jilin Province Vanguard Hospita, Changchun, Jilin Province, 130000 China

Abstract[]Objective To targeted drugs for the treatment of lung cancer with brain metastasis were analyzed.Methods From Jan鄄uary 2014 to January 2015, 66 cases of patients with brain metastases from lung cancer were randomly divided into control group and observation group, control group 33 cases patients pemetrexed combined comer west treatment, observation of the treatment group of 33 patients with treatment, compared two groups of patients with the treatment effects, and the incidence of adverse reac鄄tions.Results The treatment group effective rate was 57.58%, the control group treatment effective rate was 24.24%, the efficient treatment of observation group was obviously higher than that of control group (P<0.05), the difference is statistically significant.The incidence rate of adverse reaction of two groups of patients have no significant difference (P>0.05).Conclusion For the treat鄄ment of patients with brain metastases from lung cancer using treatment can effectively improve the treatment effect, reduce the in鄄cidence of adverse reactions, is worthy of reference for clinical promotion.

[Key words]Pemetrexed; The treatment for; Brain metastases from lung cancer

肺癌为临床常见性恶性肿瘤，约有25%的患者会出现脑转移[1]。吉非替尼是表皮生长因子受体酪氨酸激酶的抑制剂，能够有效阻断肿瘤细胞信号传递，抑制癌细胞的转移与增殖。该院于2014年1月—2015年1月对肺癌脑转移患者采用吉非替尼治疗，取得理想效果，现报道如下。

1　资料与方法

1.1一般资料

该院2014年1月—2015年1月共收治66例肺癌脑转移患者，所有患者均经MRI或CT检查存在明确脑转移病灶，颅内及颅外存在1个及以上可测量病灶；经血常规与相关检查存在未合并严重器官功能衰竭。将其随机分为对照组和观察组，对照组33例患者，其中男19例，14例；……