血必净注射液对重症肺炎患者炎症因子的影响

邱实

河南省人民医院重症医学科，河南郑州450003

[摘要]目的研究血必净注射液对重症肺炎患者炎症因子的影响。方法随机抽取2014年3月—2015年2月该院收治于ICU的重症肺炎患者60例，随机均分成观察组（n=30）和对照组（n=30），均给予常规抗感染及营养支持、加强痰液引流、免疫调节、机械通气等对症支持治疗，观察组在此基础上加用血必净注射液抗炎治疗（50 mL，q12 h）。两组患者持续给药2周后对比疗效及炎症因子相关指标变化情况。结果观察组治疗后总有效率90.0%显著高于对照组63.3%，差异有统计学意义（P<0.05）；两组患者治疗前血清IL-1、IL-6和TNF-α水平差异无统计学意义（P>0.05）；治疗后观察组患者血清IL-1(118.67± 9.01）pg/L、IL-6(79.68±14.82)pg/L、TNF-α(13.68±5.41)mg/L与治疗前比较明显降低，与对照组比较下降水平显著，差异均有统计学意义（P<0.05）。结论血必净注射液能有效降低重症肺炎患者炎症因子水平，疗效好，值得临床推广。

[关键词]血必净；重症肺炎；炎症因子

[中图分类号]R5

[文献标识码]A

[文章编号]1674-0742（2015）10（a）－0123-03

[作者简介]邱实（1984.8-），女，河南焦作人，硕士，住院医师，研究方向：重症医学科。

Abstract[]Objective To study the effect of Xuebijing injection on inflammatory factor of patients with severe pneumonia.Meth鄄ods 60 patients with severe pneumonia admitted into ICU of the hospital from March 2014 to February 2015 were selected and randomly divided into the observation group (n=30) and the control group (n=30).All of the patients were treated with routine antiinfection and nutritional support, strengthened sputum drainage, immune regulation, mechanical ventilation, symptomatic and sup鄄portive treatment.Based on this, the observation group were given Xuebijing injection anti-inflammatory treatment（50 mlq12h）.After 2 weeks of continuous administration, the changes of efficacy and inflammatory factors related indicators of the two groups were compare.Results In the observation group, the total effective rate was 90.0% which was significantly higher than 63.3% of the control group and the difference was statistically significant (P<0.05); The differences in the levels of serum IL-1, IL-6 and TNF-αin the two groups before the treatment were not statistically significant (P>0.05); After the treatment, serum IL-1 (118.67± 9.01）pg/L, IL-6 (79.68±14.82)pg/L and TNF-α(13.68±5.41) mg/L decreased significantly, compared with those before the treat鄄ment.Compared with the control group, the descending level was significantly and the differences were statistically significant (P<0.05).Conclusion Xuebijing injection can effectively reduce the level of inflammatory factors in patients with severe pneumonia and the curative effect is good, which is worthy of promotion.

收稿日期：（2015-07-05）

Effect of Xuebijing Injection on Inflammatory Factor of pPatients with Se鄄vere Pneumonia

QIU Shi

ICU of Henan People's Hospital, Zhengzhou, Henan Province, 450003 China

[Key words]Xuebijing; Severe pneumonia; Inflammatory factors

肺炎是常见的呼吸系统感染性疾病之一，属于下呼吸道感染，起病急，最常见的病因是细菌感染，抗感染治疗是肺炎治疗的主要环节，临床主要有咳嗽、伴有或不伴有咳痰、咳血、发烧、寒战、乏力、多汗、食欲减退、肌肉酸痛等全身症状。重症肺炎患者除了以上症状外可在短时间内出现意识障碍、休克、肝肾功能不全等

其他系统表现[1]。滕寅,肖家荣,林鹏[2]等医者表示炎症因子与患者重要器官功能衰竭有关，能反映重症肺炎患者的疾病严重程度，血必净注射液能化瘀解毒，可配合治疗多器官功能失常综合征，该研究使用血必净注射液对该院2014年3月—2015年2月收治的重症肺炎患者进行抗炎治疗，现报道如下。……