血清异常凝血酶原检测在肝癌患者中的应用

傅美丽

东海县人民医院检验科，江苏连云港222300

[摘要]目的探讨血清异常凝血酶原检测在肝癌患者中的诊断价值及其意义。方法随机选取2012年4月—2014年4月该院收治的100例原发性肝癌患者资料进行分析，将其设置为实验组，同期选择100例非原发性肝癌患者作为对照组，入选患者均检测血清异常凝血酶原，分析血清异常凝血酶原检测在肝癌患者中的检测效果。结果实验组原发性肝癌患者AFP指标，血清异常凝血酶原指标，显著高于对照组其他疾病患者（P<0.05）；慢性肝病、消化道肿瘤、继发性肝癌以及其他肝脏疾病患者相比血清AFP和血清异常凝血酶原显著低于对照组（P<0.05）；血清异常凝血酶原诊断符合率、阳性预测值、阴性预测值，显著高于单一甲胎蛋白检测（P<0.05）；血清异常凝血酶原联合甲胎蛋白检测特异性、符合率、阳性预测值，显著高于甲胎蛋白和血清异常凝血酶原（P<0.05）。结论肝癌患者治疗过程中检测血清异常凝血酶原效果理想，且检测过程中联合甲胎蛋白能够提高患者敏感性和特异性。

[关键词]血清异常凝血酶原；肝癌；诊断价值；意义

[中图分类号]R7

[文献标识码]A

[文章编号]1674-0742（2015）10（a）－0116-03

[作者简介]傅美丽（1981.11-），女，江苏东海人，硕士研究生，中级，主要从事临床检验技术的研究工作。

Abstract[]Objective To evaluate the clinical value and significance of serum abnormal prothrombin in diagnosis of patients with liver cancer.Methods 100 patients with primary liver cancer admitted to our hospital between April 2012 and April 2014 were included in the study and were assigned to the experimental group, and other 100 patients with non-primary liver cancer were assigned to the control group.Detection of serum abnormal prothrombin was performed on all the patients included to determine its diagnostic effect.Results The AFP and serum abnormal prothrombin levels were all significantly higher in the experimental group than in the control group (P<0.05); The AFP and serum abnormal prothrombin levels were significantly lower in patients with chronic liver disease, digestive tract cancer and other liver diseases than those in the control group (P<0.05); diagnostic accuracy, positive predictive value and negative predictive value were of serum abnormal prothrombin were significantly higher than those of Alpha-fetoprotein（P<0.05）; diagnostic accuracy, positive predictive value and negative predictive value of serum abnormal prothrombin in combination with Alpha-fetoprotein were significantly higher than those of serum abnormal prothrombin and Alpha-fetoprotein alone（P<0.05）.Conclusion Serum abnormal prothrombin in clinical diagnosis of patients with liver cancer can bring ideal effect, and it combined with Alpha-fetoprotein can improve the sensitivity and specificity of the detection.

收稿日期：（2015-07-08）

Application of Serum Abnormal Prothrombin in Clinical Diagnosis of Patients with Liver Cancer

FU Mei-li

Department of Clinical Laboratory, Donghai County People's Hospital, Lianyungang, Jiangsu Province, 222300 China

[Key words]Abnormal serum prothrombin; Liver cancer; Diagnostic value; Meaning

原发性肝癌（primary hepatocellular carcinoma）是临床上常见的疾病，这种疾病发病率较高，且随着人们生活节奏的加快其发病率出现上升趋势，它是全世界第五大癌症，占癌症死亡人数的第三位。目前，临床上对于肝癌尚缺乏理想的诊断方法，常规方法主要依赖影像学检查或肝组织病理活检等方法，这些方法虽然能够帮助患者诊断，但是特异性和敏感性较差[1]。因此，临床上研究积极有效的血清肿瘤标志物加强肝癌诊断具有重要的意义。近年来，血清异常凝血酶原检测在肝癌患者中广为使用，且效果理想，它是一种特异性较强的原发性肝癌标志物[2]。为了探讨血清异常凝血酶原检测在肝癌患者中的诊断价值及其意义，随机选取2012年4月—2014年4月该院收治的100例原发性肝癌患者资料进行分析，现报道如下。……