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伽马刀治疗脑动静脉畸形的远期疗效分析

2015-11-13王跃刚

中外医疗 2015年28期

伽马刀治疗脑动静脉畸形的远期疗效分析

王跃刚

长春市第二医院伽马刀治疗中心,吉林长春130062

[摘要]目的探讨伽马刀治疗脑动静脉畸形的远期疗效。方法对中心2010年1月—2014年1月间收治的230例AVM患者进行治疗,随机分为两组各115例,观察组给予伽马刀治疗,对照组给予血管内栓塞治疗,比较两组远期疗效。结果观察组畸形血管完全闭塞为61.7%,对照组畸形血管完全闭塞为22.6%,疗效明显优于对照组(P<0.05);观察组在临床症状改善和并发症发生方面也明显优于对照组(P<0.05)。结论伽马刀治疗AVM远期效果显著,值得应用。

[关键词]伽马刀;介入栓塞;脑动静脉畸形

[中图分类号]R815

[文献标识码]A

[文章编号]1674-0742(2015)10(a)-0085-02

[作者简介]王跃刚(1972.10-),男,辽宁康平人,本科,副主任医师,研究方向:体部肿瘤立体定向放射治疗。

Abstract[]Objective To investigate the long-term efficacy of gamma knife treatment for cerebral arteriovenous malformation (AVM).Methods 230 cerebral AVM patients admitted to this center from January 2010 and January 2014 were randomized to undergo gamma knife treatment (the observation group, n=115) and endovascular embolization therapy (the control group, n=115), and the long-term efficacy were compared between the two groups.Results The complete obliteration rate was 61.7% in the observation group and 22.6% in the control group, and the former was significant higher than the latter with statistical difference, P<0.05; in terms of improvement of symptom and complication rate, the observation group was significant superior to the control group, P<0.05.Conclusion Gamma knife treatment has remarkable long-term efficacy in management of cerebral AVM and is worthy of application.

收稿日期:(2015-07-07)

Long-term Efficacy of Gamma Knife Treatment for Cerebral Arteriovenous Malformations

WANG Yue-gang

Gamma Knife Treatment Center, Changchun Second Hospital, Changchun, Jilin Province, 130062 China

[Key words]Gamma knife; Interventional embolization; Cerebral arteriovenous malformation

脑动静脉畸形(AVM)是临床常见的先天性局部脑血管发育异常而致畸形的一种病症[1]。据报道[2],脑动脉静脉畸形占脑血管畸形的60~90%。临床上治疗AVM的方法很多,近年来临床为AVM的伽马刀治疗提供了完整、有效的技术资料和病例[3]。为探讨伽马刀治疗AVM的远期疗效,中心对2010年1月—2014年1月间采用伽马刀治疗的115例AVM患者治疗后远期观察,现报道如下。

1 资料与方法

1.1一般资料

整群选取中心2010年1月—2014年1月间收治的AVM患者230例为研究对象,均经DSA、MRA及CTA检查确诊[4]。随机将患者分为两组各115例,观察组男41例,女74例,年龄8~65岁,平均(33.7±1.3)岁;病灶最大径5.6~33.2 mm,平均21.4 mm。头痛72例,癫痫41例,感觉/运动功能缺失33例,伴颅内出血11例,蛛网膜下腔出血4例。Spetzler-Martin分级:Ⅰ~Ⅲ级72例,Ⅲ~Ⅵ级43例。……

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