HIF- 1α和HIF- 2α在高原藏族胃癌中的表达及其意义

2015-11-13刘科,朱敏侠,蔡鹏等

中外医疗 2015年28期

关键词：胃癌

刘科1，朱敏侠2，蔡鹏2，刘晓丽2

1.西藏军区总医院普通外科，西藏拉萨850000；2.西藏民族大学生命科学基础实验室，陕西咸阳712082

[摘要]目的探讨HIF-1α和HIF-2α在高原藏族胃癌中的表达及其意义。方法整群选取2013年4月—2014年4月该院收治的40例胃癌患者资料进行分析，将其设置为实验组，选择同期入院的40例非胃癌患者作为对照组，采用免疫组化SP法检测入选患者组织中的HIF-1α和HIF-2α以及VEGF表达，分析其在高原藏族胃癌中的表达及其意义。结果胃癌患者HIF-1α阳性表达率62.5%，显著高于对照组（P<0.05）。HIF-2α阳性表达率为37.5%，显著高于对照组（P<0.05）；VEGF阳性率为65%，显著高于对照组（P<0.05）。HIF-1α和淋巴结转移和TNM临床分期关系密切（P<0.05）；HIF-2α和年龄、分化程度以及淋巴结转移等无相关性（P>0.05）；VEGF表达和淋巴结转移、浸润深度以及临床TNM分期关系密切（P<0.05）；高原藏族胃癌患者中VEGF和HIF-1α表达为正相关（P<0.05）；与HIF-2α无相关性（P>0.05）。结论HIF-1α和HIF-2α因子的表达和高原藏族胃癌的发生和发展具有紧密的联系，治疗时加强低氧诱导因子监测，可能对临床治疗方案具有一定的指导意义。

[关键词]HIF-1α；HIF-2α；高原藏族胃癌；表达

[中图分类号]R5

[文献标识码]A

[文章编号]1674-0742（2015）10（a）－0072-03

[作者简介]刘科（1978.7-），男，四川威远人，硕士研究生，主治医师，主要从事胃肠疾病的基础和临床研究的工作。

[通讯作者]刘晓丽（1981.6-），女，山西右玉人，硕士研究生，讲师，主要从事血液肿瘤疾病的研究工作。

Abstract[]Objective To investigate the expression of HIF-1αand HIF-2α in tibetan plateau patients with gastric cancer and its significance.Methods 40 patients with gastric cancer admitted to the hospital between April 2013 and April 2014 were assigned to the observation group and other 40 people without gastric canner in the same period were assigned to the control group.The expression of HIF-1α and HIF-2α and VEGF in gastric cancer tissue was determined using immunohistochemical SP method, and its significance was analyzed.Results The HIF-1α-positive rate, HIF-2α-positive rate and VEGF-positive rate were 62.5%, 37.5%, 65% respectively in the observation group, all significantly higher than those in the control group, P<0.05.There were close relationship between the expression HIF-1α and lymph node metastasis and TNM clinical stage, P<0.05; No correlation was found between the expression of HIF-2α and age, degree of differentiation and lymph node metastasis, P>0.05; there were close correlation between the expression of VEGF and lymph node metastasis, depth of invasion and clinical TNM staging, P<0.05.The expression of VEGF HIF-1α expression was positively correlated with that of HIF-1α(P<0.05), but was not correlated with that of HIF-2α(P>0.05).Conclusion The expression of HIF-1α and HIF-2α are closely related to the occurrence and development of gastric cancer in tibetan plateau patients.Strengthening monitoring on hypoxia inducible factor may have some significance for clinical treatment.

收稿日期：（2015-07-08）

[基金项目]2015年西藏自治区自然科学基金项目：HIF-1α、HIF-2α在高原藏族胃癌免疫逃逸中的作用和机制（2015ZR-13-15）。

Expression of HIF-1α and HIF-2α in Tibetan Plateau Patients with Gastric Cancer and Its Significance

LIU Ke1, ZHU Min-xia2, CAI Peng2, LIU Xiao-li2

1.Department of General Surgery, General Hospital of Tibet Military Area Command, Lhasa, Tibet Autonomous Region, 850000 China;2.Life Science Laboratory, Tibetan Ethnic University, Xianyang, Shaanxi Province, 712082 China

[Key words]HIF-1α; HIF-2α; Gastric Tibetan plateau; Expression