降钙素原检测在新生儿感染性疾病中的应用

杨继英

云南省第三人民医院儿科，云南昆明650000

[摘要]目的探讨血清降钙素原(PCT)在新生儿感染性疾病应用价值。方法将该院儿科2013年12月—2014年12月收治的288例住院新生儿分别归入重症感染组（64例）、一般感染组（132例）、非感染组（92例），采用电化学发光法检测患儿血清降钙素原(PCT)水平变化。结果一般感染组132例，降钙素原阳性46例，阳性率34.85%，阴性86例；重症感染组64例，降钙素原阳性40例，阳性率62.5%，阴性24例；非感染组92例，降钙素原阳性9例，阳性率9.78%，阴性83例。重症感染组PCT阳性率最高，一般感染组其次，非感染组阳性率最低，差异有统计学意义（P＜0.05）；所有患儿血清降钙素原值随病情的好转而降低，差异有统计学意义（P＜0.05）。结论①通过检测288例患儿血清PCT水平可以明确患儿的感染情况，可有效鉴别细菌感染；②新生儿肺炎有多种病因，并非细菌感染一种，PCT检测可作为新生儿感染性肺炎的鉴别指标，为临床合理使用抗生素提供理论依据。

[关键词]血清降钙素原；新生儿肺炎；新生儿败血症；高胆红素血症

[中图分类号]R4

[文献标识码]A

[文章编号]1674-0742（2015）10（a）－0038-02

[作者简介]杨继英(1967-)，女，云南鹤庆人，本科，副主任医师，主要从事儿科临床工作。

Abstract[]Objective To investigate the value of serum procalcitonin (PCT) applied to neonatal infectious diseases.Methods 288 neonates hospitalized in Department of Pediatrics of our hospital from December 2013 to December 2014 were divided into severe infection group (64 cases), general infection group (132 cases), non-infected group (92 cases).Electrochemical luminescence method was used to test the level of serum PCT in the neonates.Results Of the 132 cases in the general infection group, 46 cases had positive procalcitonin with the positive rate of 34.85%, 86 cases had negative procalcitonin.Of the 64 cases in the severe infection group, 40 cases had positive procalcitonin with the positive rate of 62.5%, 24 cases had negative procalcitonin.Of the 92 cases in the non-infected group, 9 cases had positive procalcitonin with the positive rate of 9.78%, 83 cases had negative procalcitonin.The severe infection group had the highest positive rate of PCT, followed by the general infection group, and the non-infected group had the lowest positive rate of PCT with statistically significant difference (P<0.05).The level of PCT in all the neonates decreased as the disease improved with statistically significant difference (P<0.05).Conclusion①The infection of the neonates and bacterial infection can be effectively identified by testing the level of serum PCT in 288 neonates.②Many reasons including bacterial infection can cause neonatal pneumonia.PCT testing can be used as the identification index of neonatal infectious pneumonia, which provides a theoretical basis for the clinical rational use of antibiotics.

收稿日期：（2015-06-23）

Test of Serum Procalcitonin Applied to Neonatal Infectious Diseases

YANG Ji-ying

Department of Pediatrics, The Third People's Hospital of Yunnan Province, Kunming, Yunnan Province, 650000 China

[Key words]Serum procalcitonin; Neonatal pneumonia; Neonatal sepsis; Hyperbilirubinemia

感染性疾病是由细菌或病毒感染而导致的疾病，是新生儿科常见的疾病类型之一[1]。严重者可导致脓毒血症、败血症、多器官功能衰竭等，甚至导致新生儿死亡。调查显示，近几年，我国新生儿感染性疾病的发病率明显上升，给儿科医学工作者带来了较大的困难。……