胡翔

【摘 要】目的：分析产前超声在胎儿全前脑畸形诊断中的应用价值。方法：选择2009年5月至2014年8月在我院接受产前超声检查被诊断为胎儿全前脑畸形的20例孕妇的临床资料进行回顾性分析，观察胎儿颅内结构、大脑Willis动脉环结构及血流情况、颜面部器官以及其他器官合并畸形情况。结果：在20例全前脑畸形胎儿中，12例为无叶全前脑、7例为半叶全前脑，且均伴有颜面部畸形，主要表现为独眼畸形、眼距过近、单鼻孔、无鼻孔长鼻畸形或象鼻畸形、小口畸形及中央型唇腭裂；同时2例伴有双手及双足轴后多指（趾）畸形，2例同时合并脐膨出。1例叶状全前脑，未合并颜面部及其他器官畸形。CDFI显示部分全前脑胎儿大脑Willis动脉环灌注存在异常或者存在反向血流现象，结构缺乏完整性。結论：产前超声能够无创、敏感地检出胎儿全前脑畸形及其合并畸形，并且可对全前脑畸形进行分型，对指导产前咨询及临床处理具有重要意义。

【关键词】超声检查；胎儿；全前脑畸形

The value of prenatal ultrasound diagnosis of holoprosencephaly.

Hu Xiang

Xingyi People's Hospital of Guizhou Province Department of medical ultrasound 562400

[Abstract]Objective：To analyze the application value of prenatal ultrasonography in diagnosis of fetal holoprosencephaly. Methods：From 2009 May to 2014 year in August in our hospital for prenatal ultrasound diagnosis for clinical data of 20 cases of pregnant women of fetal holoprosencephaly. Were analyzed retrospectively， observation of fetal intracranial structure， ring structure and blood flow of the brain artery of Willis， the facial organs and other organs combined anomalies. Results：In 20 cases of fetal holoprosencephaly， 12 cases with alobar holoprosencephaly， 7 cases with semilobar holoprosencephaly， and were associated with facial deformities， mainly manifested as cyclopia， eyes from too close， single nostril nose deformity or trunk， trunk deformity， malformed and central type of cleft lip and palate at the same time； 2 cases with both hands and feet shaft multi finger （toe） malformation， 2 cases combined with omphalocele. 1 cases of phyllodes holoprosencephaly， not complicated with facial deformities and other organs. CDFI display part of the forebrain of fetal cerebral arterial circle of Willis perfusion abnormal or there is a reverse flow phenomenon， the lack of integrity of the structure. Conclusion：Prenatal ultrasound is a non invasive， sensitive in detecting fetal holoprosencephaly and malformation， and of holoprosencephaly type， is of great significance to guide the prenatal counseling and clinical treatment.

[Key words]Ultrasonography； Fetus； Holoprosencephaly

全前脑又被称为前脑无裂畸形（HPE），是一种较为少见的中枢神经系统畸形疾病，其发生率较低[1]。胎儿一旦存在全前脑畸形，存活极低，因此应加强产前诊断，及时发现胎儿是否存在全前脑畸形。本次研究主要对产前超声在全前脑畸形诊断中的应用价值进行分析，现报告如下。

1 资料与方法

1.1 一般资料

选取2009年5月至2014年8月在我院接受超声检查被诊断为胎儿存在全前脑畸形的20例孕妇的临床诊断资料作为研究对象。……