周怡等

[摘要] 目的 评价胃铋镁颗粒对服用常规剂量阿司匹林患者胃黏膜的保护作用。 方法 选择包头医学院第二附属医院心内科2013年4～9月住院及首次服用常规剂量阿司匹林的96例患者为研究对象，将其分为对照组（50例）及观察组（46例），每组各脱落2例。对照组服用阿司匹林100 mg/d，疗程3个月；观察组在对照组的基础上，口服胃铋镁颗粒，1袋/次，3次/d，疗程3个月。用药1、3个月后复查三大常规、粪便隐血试验、血肝肾功能，用药3个月后复查胃镜。比较两组服药后上消化道症状及胃黏膜损伤发生率。 结果 对照组上消化道症状及胃黏膜损伤发生率分别为35.4%、39.6%，观察组上述指标分别为18.2%、25.0%，两组比较差异均有统计学意义（P < 0.05）。 结论 胃铋镁颗粒对服用常规剂量阿司匹林造成的胃黏膜损伤具有保护作用。

[关键词] 胃铋镁颗粒；阿司匹林；上消化道症状；胃黏膜损伤；非甾体类抗炎药

[中图分类号] R285.5 [文献标识码] A [文章编号] 1673-7210（2015）02（b）-0115-04

[Abstract] Objective To evaluate protective effect of Compound Bismuth and Magnesium Granules on gastric mucosal injury induced by regular doses of Aspirin. Methods 96 hospitalized patients who were treated with regular doses of Aspirin for the first time， in Cardiology Department in the Second Affiliated Hospital of Baotou Medical College from April to September 2013， were divided into control group （50 cases） and observation group （46 cases）， 2 cases fell off from each group. All patients were given Aspirin 100 mg/d for 3 months； the observation group was added Compound Bismuth and Magnesium Granules， 1 bag/time， 3 times/d for 3 months. After treated for one month and three months， all patients were given reexamination of the three conventional， fecal occult blood test， liver and kidney function， and the gastroscopy after treated for three months. After treatment， the incidence of upper gastrointestinal symptoms and gastric mucosal injury incidence were compared between the two groups. Results The incidence of gastrointestinal symptoms and gastric mucosal injury incidence of the control group were 35.4%， 39.6%， respectively； the two indicators of the observation group were 18.2%， 25.0%， respectively. The two results between the two groups had statistically significant differences （P < 0.05）. Conclusion Compound Bismuth and Magnesium Granules can protect the gastric mucosa against injury by regular doses of Aspirin.

[Key words] Compound Bismuth and Magnesium Granules； Aspirin； Upper gastrointestinal symptoms； Gastric mucosal injury； NSAIDs

阿司匹林因可防止血栓形成和减少心血管事件，所以在心血管疾病患者尤其是老年患者中应用广泛。目前循证医学证据支持的阿司匹林长期预防剂量为75～100 mg/d[1]。而长期服用常规剂量的阿司匹林能增加胃黏膜损害，引起糜烂、溃疡，甚至消化道出血。因此在临床使用中，阻止非甾体类抗炎药（NSAID）引起的胃黏膜损害显得非常重要。本研究旨在对服用常规剂量阿司匹林的患者进行研究，观察胃铋镁颗粒对阿司匹林所致胃黏膜损伤的保护作用。现将结果报道如下：

1 资料与方法

1.1 一般资料

选择2013年4～9月包头医学院第二附属医院心内科住院、首次服用常规剂量阿司匹林的患者96例，将其分为对照组（50例）及观察组（46例）。……