选择性血管结扎在手术治疗动静脉畸形中的应用
2015-03-11胡正祥等
胡正祥等
[摘要] 目的 探讨选择性血管结扎后平阳霉素血管腔内注射联合手术切除治疗肢体动静脉畸形的临床疗效。 方法 26例肢体动静脉畸形患者术前均行血管造影,A组15例术中分离结扎病灶主要供血血管,用平阳霉素于结扎血管腔内注射后病灶切除,B组11例术中不结扎主要供血血管,观察分析术后临床疗效。 结果 26例患者术后随访1~12个月,其中A组治愈占80.0%(B组63.6%),显效13.3%(B组18.2%),好转6.7%(B组18.2%),两组疗效差异有统计学意义(Z=-2.975,P<0.05)。 结论 选择性血管结扎后平阳霉素腔内注射联合手术切除治疗肢体动静脉畸形是一种安全、有效的治疗方法。
[关键词] 平阳霉素;动静脉畸形;手术治疗
[中图分类号] R651.2 [文献标识码] B [文章编号] 1673-9701(2015)01-0153-03
The application of selective vessel ligation in operative treatment of arteriovenous malformations
HU Zhengxiang CHEN Shijiu YANG Jun FANG Hong LI Zhi LONG Hang
Department of Plastic Surgery and Burn, the Fifth Affiliated Hospital of Zunyi Medical College,Zhuhai 519100, China
[Abstract] Objective To research the clinical effect of extremity arteriovenous malformations by combining intravascular injection of pingyangmycin with surgical excision after the vessel selectively ligated. Methods 26 patients with arteriovenous malformations were treated with combining intravascular injection of pingyangmycin with surgical excision. All the patients were diagnosed by angiography before operative treatment. Separating and ligaturing the main nutrient artery during operation in group A(15 cases),but group B(11 cases)not. Observed and evaluated the clinical effect of postoperation. Results All patients were followed up for 1-12 mouths, in group A, 80.0% were cured(63.6% in group B),13.3% markedly improved(18.2% in group B), and 6.7% improved(18.2% in group B). The curative effect between the two groups had statistical significance(Z=-2.975,P<0.05). Conclusion Combining intravascular injection of pingyangmycin with surgical excision after the vessel selectively ligated was the effective and safe way to treat extremity arteriovenous malformations.
[Key words] Pingyangmycin;Arteriovenous malformations;Operative treatment
动静脉畸形是胚胎血管发生过程中结构异常,血管内皮细胞无异常增殖,随年龄而逐渐增大,不会发生自然消退。动静脉畸形可发生于身体任何部位,以颅内、颜面部和四肢多见[1],常严重影响局部皮肤、肌体组织的结构和外观,导致畸形和功能障碍,影响患者的生活质量。目前的治疗方法有外科手术、覆膜支架、弹簧圈栓塞及硬化剂注射、凝血酶和(或)高渗葡萄糖注射、激光及放射疗法等[2]。血管畸形的治疗方法很多,各种治疗方式均有其适用范围、治疗优势和缺陷。2012年5 月~2014年5月我院采用选择性血管结扎后平阳霉素管腔内注射联合手术切除治疗肢体动静脉畸形,取得了良好效果,现报道如下。
1 资料与方法
1.1 一般资料
本次选择2012年5月~2014年5月我院收治的动静脉畸形患者26例,其中男11例,女15例,年龄13~51岁,中位年龄 21岁。分为A组15例,B组11例,病变部位为前臂5例,手部2例,大腿12例,足部7例。主要表现为自幼发现局部有软组织肿块,随年龄增长,局部肤色改变、肿块增大,病变部位听诊可闻及间歇性或连续性血管杂音,引流静脉迂曲扩张。……
