戒烟对浙江省海宁市某医院男性冠心病患者血脂代谢的影响

2015-03-09乔红元

医学与社会 2015年10期

关键词：冠心病

乔红元

浙江省海宁市中医院，海宁，314400

戒烟对浙江省海宁市某医院男性冠心病患者血脂代谢的影响

乔红元

浙江省海宁市中医院，海宁，314400

摘要目的:了解冠心病患者戒烟后血脂代谢的变化。方法：选取浙江省海宁市某医院80例有吸烟史的冠心病患者随机分为戒烟组和吸烟组，每组40例，分别在戒烟第0个月、3个月、6个月及12个月检测血清血脂水平，并观察2组患者主要心血管事件发生率。结果: 冠心病患者戒烟第3个月、6个月、12个月血清TC、TG、LDL-C较戒烟第0个月下降(P<0.05﹚，血清HDL-C水平较戒烟第0个月显著升高(P<0.05)，与吸烟组比较差异具有统计学意义(P<0.05)。经过12个月随访观察，戒烟组与吸烟组冠心病患者均未出现心源性死亡事件；2组心血管事件发生率无显著性差异(P>0.05)；戒烟组再住院率为7.5%，显著低于吸烟组(25.0%)，差异具有统计学差异(P﹤0.05)。结论: 戒烟能在较短时间内降低冠心病患者血清TC、TG、LDL-C水平，升高血清HDL-C水平，减少冠心病患者再住院率。

关键词戒烟；冠心病；血脂代谢

Influence of Quitting Smoking on Lipid Metabolism in Male Patients with Coronary Heart Disease

Qiao Hongyuan

ChineseMedicineHospitalinHainingCityofZhejiangProvince,Haining, 314400

AbstractObjective: To understand the changes of lipid metabolism in male patients with coronary heart disease after smoking cessation. Methods: 80 cases with coronary heart disease who were smoking were randomly divided into two group- smoking cessation group and control group, and each group had 40 cases. Lipids were monitored after 3 months, 6 months and 12 months in quitting smoking, and the influence of coronary events was investigated. Results: Serum TC, TG and LDL-C decreased after 3 months, 6 months and 12 months in smoking cessation(P<0.05) while HDL-C significantly increased (P<0.05), compared with the control group. After 12-month follow-up, cardiac death did not occur in patients of both groups. The rate of cardiovascular event had no significant difference between two groups (P>0.05). The re-hospitalization rate of smoking cessation group was 7.5%, which was significantly lower than 25% of the control group (P<0.05). Conclusion: Serum TC, TG and LDL-C can be reduced and serum HDL-C can be risen in a relatively short time after smoking cessation, and the rate of re-hospitalization can be reduced in patients with coronary heart disease.

Key WordsSmoking Cessation; Coronary Heart Disease; Lipid Metabolism

冠状动脉粥样硬化性心脏病(coronary atherosclerotic heart disease，CHD)，简称冠心病，也称缺血性心脏病，已成为心脏病的主要类型，吸烟是冠心病的独立危险因素。在接受冠脉造影的患者中，吸烟者冠脉造影阳性率显著高于不吸烟者，吸烟是冠脉造影阳性的预测因素[1]。对于冠心病患者，戒烟是一种完全可控且收益巨大的干预措施，但戒烟影响心血管系统的机制仍未阐明，其中对冠心病患者血脂代谢的影响更是鲜有报道。本研究观察了80例有吸烟史的冠心病患者，检测戒烟前后血脂水平变化，探讨戒烟对冠心病患者血脂代谢的影响。

1 资料来源与方法