吕微 王先哲 陈莹莹 崔成都 娄安钢

摘要 采用病理解剖学和病理组织学技术对1例疑似大叶性肺炎而死亡的红色荧光转基因五指山猪进行病理诊断。结果表明，病猪主要病变体现在肺脏，肺充满整个胸腔，表面附有絮状渗出物，呈灰红色，局部可见暗红色的出血斑，质硬如肝，切面干燥，投入水中完全下沉；显微镜下主要呈现大叶性肺炎的红色肝变期和灰色肝变期的病变特点，心、肝、肾、脾、胰腺等其他器官充血，可见轻微的细胞变性，结合其临床症状，确诊为大叶性肺炎。此外，死亡红色荧光转基因五指山猪的各组织器官呈红色，颜色深浅因不同器官而有差异。这将为进一步探讨红色荧光转基因猪的研究提供病理学基础资料。

关键词 红色荧光转基因五指山猪；大叶性肺炎；病理学

中图分类号 S828 文献标识码 A 文章编号 0517-6611（2014）31-10979-03

The Pathological Observation of Lobar Pneumonia of the Red Fluorescence Transgenic Wuzhishan Pig

LV Wei1， WANG Xianzhe1， CHEN Yingying2， LOU Angang1* et al

（1.Animal Medicine Department of Agriculture College of Yanbian University， Yanji， Jilin 133000；2.Animal Husbandry Administration Bureau in Longjing City of Jilin Province， Longjing， Jilin 133400）

Abstract The pathological anatomy and pathologic histology technology was used for the pathological diagnosis of a case of red fluorescence transgenic Wuzhishan pig died of the suspected lobar pneumonia desease. The results showed that the main pathological change of the pig was in the lung. The specific characteristics was that the lung filled the entire chest and was attached by flocculent exudate on its surface. Also， the lung was grayish red and had many dark red visible local bleeding spots and was as hard as the liver， and the section of the lung was dry and the lung completely sunk in the water. The lung appeared the pathological features of the main lobar pneumonia red and gray hepatization under the microscope. The heart， liver， kidney， spleen， pancreas and other organs congested and the slight degeneration of cells could be seen. The lobar pneumonia desease was diagnosed according to the above results and clinical symptoms. In addition， every organ of the died red fluorescence transgenic Wuzhishan pig was red and the red color depth was different among the different organs. The test results will further provide a pathological basis for the study of red fluorescence transgenic pig.

Key words Red fluorescence Wuzhishan transgenic pigs； Lobar pneumonia； Pathology

大葉性肺炎（Lobar pneumonia）是以肺泡内渗出大量纤维素为特征的急性炎症，通常又称为纤维素性肺炎。此型肺炎常侵犯一个大叶、一侧肺脏或全肺，肺组织发生大面积广泛实变为其特点^[1]。

大叶性肺炎根据其病变特点通常分为4期，各期变化是这个连续发展过程的不同阶段：①充血水肿期：大叶性肺炎的初期，发病第1～2天的变化，主要以肺泡毛细血管充血和浆液性水肿为其病变特点。临床上此期病变较轻，除一些特急性猪肺疫病例外，患畜很少死亡；②红色肝变期：由充血水肿期发展而来，一般发病第2～3天进入此期，其病变特点是肺泡壁毛细血管扩张充血，肺泡腔内有大量纤维素、红细胞渗出。……