吕淑娟　唐安洲

[摘要]肝病的危害，尤其是肝炎的流行以及肝癌的高死亡率已经成为国内外共同关注的重要卫生问题之一，由于缺乏理想的动物模型，某些肝炎及肝癌目前尚未清楚其发病的生理学机制，为了寻找有效的防治方法，建立合适的动物模型显得极其重要。树鼩在医学研究中的价值近年来受到越来越多的关注。国内外的研究发现，人们利用树鼩成功建立了多种肝脏疾病的动物模型，多数研究集中在人类病毒性肝炎及肝癌方面。本文主要介绍肝脏疾病树鼩动物模型的国内外新进展。

[关键词]树鼩；肝脏疾病；动物模型

[中图分类号] R-332 [文献标识码] A [文章编号] 2095-0616（2014）17-32-04

[Abstract] Hepatopathy damage， especially the popular of hepatitis and high-mortality of liver cancer has become one of the major health issues of common concern at home and abroad， due to the lack of ideal animal model， pathophysiological mechanisms of some hepatitis and liver cancer was not yet clear， establishing an appropriate animal mode should be extremely important in order to find effective prevention methods. The value of medical research of tree shrew had been payed more and more attention in recent years. Researches found that people established a variety of animal models with liver disease successfully by using the tree shrew， most research had focused on aspects of human viral hepatitis and liver cancer. This paper described a new progress of animal model with liver disease by tree shrews.

[Key words] Tree shrews； Liver disease； Animal models

肝脏疾病是危害人类健康的重要疾病，包括病毒性肝炎、肝硬化、肝癌、脂肪肝等，目前尚无理想的治疗方法。甲型肝炎、乙型肝炎虽有疫苗，但不能忽视未来由于病毒变异带来的威胁。丙型肝炎目前尚未发现非常有效的疫苗，且丙型肝炎的病理学机制也尚未完全清晰。针对肝脏疾病的研究以及药物研发仍有赖于良好的动物模型，非人灵长类猩猩、猴等与人亲缘相近，但用作动物模型具有个体大、难操作、繁殖慢、资源有限、研究周期长、费用昂贵等不足，为寻找良好的、简便的、实用的肝脏疾病动物模型，有众多学者把目光关注到树鼩。

树鼩（Tupaia belangeri）是一种生长于热带及亚热带地区的小型动物，属灵长目、原猴亚目（狐猴亚目）、树鼩科，也有学者认为属灵长目与食虫目之间的……