吕远  周静

[摘要] 目的 探讨神经梅毒患者血清白细胞介素-4（IL-4）、干扰素-γ（IFN-γ）的变化及其临床意义。 方法 选取2007年1月～2013年10月期间我院诊治的神经梅毒患者34例（神经梅毒组）及非神经梅毒患者34例（非神经梅毒组），选取34例正常体检者为对照组，患者在入院后及治疗1个月后、体检者在体检结束未发现有异常疾病后抽血检测IL-4、IFN-γ。 结果 三组之间IL-4、IFN-γ浓度明显存在不同（P＜0.05），神经梅毒组、非神经梅毒组IL-4、IFN-γ浓度高于对照组（P＜0.05），神经梅毒组与非神经梅毒组IL-4、IFN-γ浓度比较差异无统计学意义（P＞0.05），神经梅毒组患者在治疗后IL-4、IFN-γ浓度明显低于治疗前（P＜0.05）。 结论 神经梅毒与非神经梅毒患者均存在IL-4、IFN-γ升高变化，神经梅毒与非神经梅毒患者之间IL-4、IFN-γ无明显差异，经过治疗IL-4、IFN-γ水平会明显下降。

[关键词] 神经梅毒；白细胞介素-4；干扰素-γ

[中图分类号] R759.1   [文献标识码] A   [文章编号] 2095-0616（2014）09-22-04

Changes of serum interleukin-4 and IFN-γ in patients with neurosyphilis and their clinical significance

LV Yuan1  ZHOU Jing2

1.Department of Comprehensive Medicine, Shanwei Yihui Foundation Hospital, Shanwei 516600,China; 2.Department of Dermatology, Shanwei Yihui Foundation Hospital, Shanwei 516600,China

[Abstract] Objective To investigate the changes of serum interleukin-4(IL-4) and interferon-γ(IFN-γ) in the patients with neurosyphilis and their clinical significance. Methods Thirty-four patients with neurosyphilis(neurosyphilis group) and 34 patients with non-neurosyphilis(non-neurosyphilis group) treated in our hospital from January 2007 to October 2013 were selected, and 34 normal health examinees were selected as the control group. The patients blood was drawn to examine the IL-4 and IFN-γ after admission, 1 month after treatment and when not discovering abnormal diseases at the end of health examination. Results The three groups were significantly different in the IL-4 and IFN-γ concentrations(P＜0.05); The neurosyphilis group and the non-neurosyphilis group had higher IL-4 and IFN-γ concentrations than the control group(P＜0.05); The neurosyphilis group and the non-neurosyphilis group were not different in the IL-4 and IFN-γ concentrations, with no statistical significance(P＞0.05); The IL-4 and IFN-γ concentrations of the neurosyphilis group after treatment were significantly lower than those before treatment(P＜0.05). Conclusion Both the neurosyphilis group and the non-neurosyphilis group have elevated IL-4 and IFN-γ concentrations; The neurosyphilis group and the non-neurosyphilis group were not significantly different in the IL-4 and IFN-γ; The IL-4 and IFN-γ levels decrease significantly after treatment.

[Key words] Neurosyphilis; Interleukin-4; Interferon-γ

梅毒为梅毒螺旋体（treponema pallidum, TP）感染所致的一种慢性的性传播疾病，患者根据病情发展阶段也分为潜伏期梅毒、一期梅毒、二期梅毒、三期梅毒、先天性梅毒[1]，如患者临床症状累及到神经系统则称为神经梅毒，患者可出现头痛、呕吐、偏瘫等神经系统受累症状[2]。研究发现梅毒患者其细胞免疫存在异常变化可能是导致梅毒发病的关键

环节[3]，干扰素-γ（IFN-γ）、白细胞介素-4（IL-4）均是与T细胞免疫相关因子[4-5]，因此笔者对我院收治的神经梅毒患者血清IFN-γ、IL-4进行了检测，从而探讨神经梅毒患者血清白细胞介素-4、干扰素-γ的变化及其临床意义，现将结果报道如下。

1 资料与方法

1.1 一般资料

选取我院2007年1月～2013年10月期间诊治的神经梅毒患者34例（神经梅毒组）及非神经梅毒患者34例（非神经梅毒组），入选标准：（1）患者均通过RRP实验初筛诊断为梅毒，行TPPA试验阳性确诊。……