刘永刚

[摘要] 目的 探讨盐酸氨溴索、地塞米松联合应用治疗分泌性中耳炎的临床疗效。 方法 选择我院2012年6月～2013年6月收治的85例分泌性中耳炎患者的临床资料，将患者分为治疗组43例与对照组42例，给予全部患者常规治疗，治疗组患者给予盐酸氨溴索联合地塞米松混合液，对照组仅给予地塞米松注射液。 结果 两组有效率比较，差异有统计学意义（P<0.05）；治疗后，两组患者纯音听阈测定气导听力提高水平对比，差异有统计学意义（P<0.05）。 结论 鼓室内注射盐酸氨溴索联合地塞米松混合液治疗分泌性中耳炎具有良好的临床疗效，安全、可靠、操作简单，可临床推广应用。

[关键词] 盐酸氨溴索；地塞米松；分泌性中耳炎；临床疗效

[中图分类号] R764 [文献标识码] B [文章编号] 2095-0616（2014）04-112-04

Efficacy analysis on intratympanic injection of ambroxol hydrochloride and dexamethasone for treatment of secretory otitis media

LIU Yonggang

Department of ENT， Nanyang Central Hospital in Henan Province， Nanyang 473000， China

[Abstract] Objective To analyze and discuss the clinical efficacy of ambroxol hydrochloride and dexamethasone for treatment of secretory otitis media. Methods 85 patients with secretory otitis media admitted and treated in our hospital from Jun 2012 to Jun 2013 were selected and assigned to the treatment group （43 cases） and the control group （42 cases）. All the patients were given routine treatment. The treatment group was given ambroxol hydrochloride mixed with dexamethasone while the control group was given dexamethasone injection alone. Results The two groups had significant difference in therapeutic response rate （P<0.05）. The two groups also had significant difference in elevation of air conduction hearing ability measured by pure tone audiometry after treatment （P<0.05）. Conclusion Intratympanic injection of ambroxol hydrochloride and dexamethasone demonstrates good clinical efficacy， safety， reliability and simple operation for treatment of secretory otitis media， which is worthy of clinical promotion and application.

[Key words] Ambroxol hydrochloride； Dexamethasone； Secretory otitis media； Clinical efficacy

分泌性中耳炎是耳鼻喉科临床较为常见症状，是以鼓室积液及传导性听力损失为特点的中耳非化脓性炎症，表现为患者听力减退、传导性聋等症状，严重可引起患者听力受损、言语障碍等多种并发症，尤其是儿童，如治疗不及时，可能引发中耳粘连、硬化等病变反应，造成听力严重受损，严重影响患者的生活质量[1]。目前，治疗分泌性中耳炎主要应用药物通过抗菌、排液等为目的，但疗效不显，易反复。我院依据文献，对分泌性中耳炎患者采用盐酸氨溴索联合地塞米松鼓室内注射治疗的方法进行治疗，分析其临床应用效果及安全性，旨在为临床提供参考，现报道如下。

1 资料与方法

1.1 一般资料

选择我院耳鼻喉科2012年6月～2013年6月收治的85例分泌性中耳炎患者的临床资料，男58例，女27例；患者年龄18～40岁，平均（28.6±6.8）岁；患耳87例；病程15d～6个月，平均（3.2±0.9）个月；患者临床主要症状为有耳闷塞感、听力减退，经检查可见鼓膜内陷、混浊、夫去正常光泽，鼓膜活动性差，有液平面，另有17例患者有耳内水动感。……