祝淑平

[摘要] 目的 探讨干扰素联合LEEP刀治疗宫颈糜烂的临床效果。 方法 选取2012年1～12月来本院进行治疗的144例宫颈糜烂患者，随机将其分为观察组和对照组各72例，对照组患者单纯采用LEEP刀治疗，观察组患者采用干扰素联合LEEP刀进行治疗，比较两组患者的治疗效果。 结果 对照组总有效率为93.1%，观察组总有效率为95.8%，两组差异无统计学意义（P>0.05）。对照组治疗3、6、9个月的HPV转阴率分别为26.4%、50.0%、72.2%，观察组分别为68.1%、84.7%、94.4%，两组差异有统计学意义（P<0.05）。 结论 干扰素联合LEEP刀治疗宫颈糜烂效果良好，可以彻底干净地切除病变的糜烂组织，治愈率高，治疗效果显著，损伤程度较小，疾病恢复较快，值得临床推广应用。

[关键词] 干扰素；宫颈糜烂；临床效果

[中图分类号] R711.3 [文献标识码] A [文章编号] 1674-4721（2014）04（b）-0029-02

[Abstract] Objective To observe the clinical efficacy of interferon combined with LEEP in the treatment of cervical erosion.Methods 144 cases of patients with cervical erosion treated in our hospital from January to December 2012 were selected and randomly divided into the observation group and the control group，each group for 72 cases.The control group was treated with single LEEP，and the observation group was treated with interferon combined with LEEP.The treatment effect of two groups was compared.Results The total effective rate of the control group was 93.1%，the observation group was 95.8%，the difference was not significant （P>0.05）.The negative-converting rate of HPV after 3 months，6 months and 9 months treatment for the control group was 26.4%，50.0% and 72.2%，and that of the observation group was 68.1%，84.7% and 94.4%，the difference was significant （P<0.05）.Conclusion Interferon combined with LEEP treating cervical erosion has good treatment effect，not only can resect diseased erosion organizations of patients，has high recovery rate and evident treatment effect，but also has little injury degree and rapid recovery of diseases，which is worthy of clinical promotion and application.

[Key words] Interferon；Cervical erosion；Clinical efficacy

在已婚妇女中，宫颈糜烂属于一种比较常见的疾病，通常发生在子宫颈癌前病变中，因此在临床上也有“妇科杀手”的称号。一旦患有这种疾病且没有得到及时治疗，很容易导致盆腔深处的组织受到感染，严重的还会引起不孕[1-2]。本研究对144例宫颈糜烂患者的临床资料进行分析，探讨干扰素联合LEEP刀治疗宫颈糜烂的临床效果。

1 资料与方法

1.1 一般资料

选取2012年1～12月来本院接受治疗的144例宫颈糜烂患者，其中Ⅰ度患者32例，Ⅱ度患者71例，Ⅲ度患者41例；年龄24～49岁，平均32.5岁，均处于非妊娠期。随机将144例患者分为观察组和对照组各72例，两组患者的年龄、疾病程度等资料差异无统计学意义（P>0.05）。

1.2 治疗方法

对照组患者取膀胱截石位，采用常规消毒以后，用LEEP刀从宫颈处顺时针切除宫颈糜烂组织，切除的范围大于发生病变范围的0.3 cm，尽量保存环形的完整性，深度以0.5 cm为准，根据患者宫颈糜烂的具体情况确定深度进行锥形切除，将切下来的糜烂组织送去病检。手……