赵华 王小泉 赵红宇 万贤凤 轩东英

[摘要] 目的 分析广州地区糖尿病患者牙周炎症严重程度对血清超敏C反应蛋白水平的影响。 方法 对123名糖尿病伴牙周炎患者，145名慢性牙周炎患者进行全口牙周检查，记录PD和AL，并检测其血清hs-CRP水平。 结果 糖尿病伴慢性牙周炎组血清hs-CRP水平以及PD显著高于慢性牙周炎组，差异有统计学意义（P＜0.05）。 结论 糖尿病能够使血清hs-CRP水平升高，可能会加重牙周炎症程度。

[关键词] 牙周炎；糖尿病；超敏C反应蛋白

[中图分类号] R781.4???[文献标识码] B???[文章编号] 2095-0616（2012）15-12-03

The effect of periodontal inflammatory on the level of hs-CRP in diabetes patients with periodontitis of Guangzhou area

ZHAO?Hua1??WANG?Xiaoquan2??ZHAO?Hongyu1??WAN?Xianfeng3??XUAN?Dongying2

1.Department of Periodontology,the Stomatological Hospital Affiliated Southern Medical University,the Panyu Branch of Stomatological Hospital of Guangdong Province, Guangzhou 510400, China;2. Department of Periodontology, the Stomatological Hospital Affiliated Southern Medical University,the Stomatological Hospital of Guangdong Province, Guangzhou 510280,China; 3.Department of Orthodontics,the Stomatological Hospital Affiliated Southern Medical University,the Panyu Branch of Stomatological Hospital of Guangdong Province, Guangzhou 510400

[Abstract] Objective To analyze the effect of periodontal inflammatory on the level of hs-CRP in diabetes patients with periodontitis of Guangzhou area. Methods All of participants, 123 cases of diabetes patients with chronic periodontitis and 145 cases of chronic periodontitis, were asked to complete full-mouth periodontal assessment and blood sample analysis. Periodontal examinations, including probing depth, bleeding on probing, clinical attachment level, were recorded. The level of hs-CRP was measured. Results The level of hs-CRP and PD in diabetes with chronic periodontitis group was higher than chronic periodontitis group,the difference was statistically significant(P＜0.05). Conclusion Periodontal inflammatory may rise the level of fasting blood sugar in type 2 diabetes with chronic periodontitis patients.

[Key words] Chronic periodontitis;Diabetes;High sensitive C-reactive protein

目前认为，糖尿病是一种系统性的慢性炎症，炎症被认为是糖尿病重要的始发因素，炎症的存在不利于糖尿病血糖的控制。牙周炎会使促进机体分泌一系列的炎症介质，炎症介质释放入血，可以影响糖代谢，最终导致胰岛素抵抗[1-2]。C反应蛋白（high sensitive C-reactive protein，hs-CRP）是经典的非特异性炎症标志物，CRP在牙周炎和糖尿病的相关关系中可能发挥着重要作用。

1?资料与方法

1.1?一般资料

收集2005～2011年番禺疗养院糖尿病伴牙周炎患者，均为hs-CRP＜10 mg/L的对象，共268例，男186例，女82例，平均年龄（50.11±9.18）岁；入选者签署知情同意书、填写调查问卷表，调查问卷内容包括身高、体重、血压、饮酒、吸烟、口

腔卫生等。其中糖尿病伴牙周炎患者（A组）123例：患牙周炎同时伴有冠心病。纳入标准：糖尿病确诊1年以上，无严重并发症；患有慢性牙周炎，未经过系统牙周治疗，1年内未接受过治疗。慢性牙周炎组（B组）145例：无全身系统性疾病，患有牙周炎。糖尿病的诊断标准（1999年WHO诊断标准）：伴有糖尿病症状及任意时间血浆葡萄糖＞11.1 mmol/L；……